User profiles for Scott D. Larsen

Scott D. Larsen

Research Professor of Medicinal Chemistry
Verified email at med.umich.edu
Cited by 6254

Aza Diels-Alder reactions in aqueous solution: cyclocondensation of dienes with simple iminium salts generated under Mannich conditions

SD Larsen, PA Grieco - Journal of the American Chemical Society, 1985 - ACS Publications
Compared to the all-carbon Diels-Alder reaction, the imino variation has received only scant
attention, despite the enormous potential it holds for alkaloid synthesis. 1· 2 The vast …

X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases

…, NM Davis, SC Baker, SD Larsen… - Journal of Medicinal …, 2014 - ACS Publications
Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar
potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A …

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β–induced fibrogenesis in human colonic myofibroblasts

…, ES Rodansky, AJ Haak, SD Larsen… - Inflammatory bowel …, 2014 - academic.oup.com
Background Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil forming
protein kinase signaling is a key pathway in multiple types of solid organ fibrosis, including …

[HTML][HTML] Redox modification of nuclear actin by MICAL-2 regulates SRF signaling

MR Lundquist, AJ Storaska, TC Liu, SD Larsen… - Cell, 2014 - cell.com
The serum response factor (SRF) binds to coactivators, such as myocardin-related
transcription factor-A (MRTF-A), and mediates gene transcription elicited by diverse signaling …

[HTML][HTML] Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis

…, ES White, Y Zhou, PDR Higgins, SD Larsen… - The American journal of …, 2015 - Elsevier
Myofibroblasts are crucial to the pathogenesis of tissue fibrosis. Their formation of stress
fibers results in the release of myocardin-related transcription factor (MRTF), a transcriptional …

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

…, M Wilson, K Jorgensen-Muga, SD Larsen… - Nature chemical …, 2017 - nature.com
The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system promotes
the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help drive the …

[PDF][PDF] A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells

…, C Landen, B Cravatt, TD Hurley, SD Larsen… - Cell reports, 2019 - cell.com
Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy
resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, …

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole …

C Liljebris, SD Larsen, D Ogg, BJ Palazuk… - Journal of medicinal …, 2002 - ACS Publications
Protein tyrosine phosphatases (PTPs) constitute a diverse family of enzymes that, together
with protein tyrosine kinases, control the level of intracellular tyrosine phosphorylation, thus …

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor–regulated gene transcription prevent fibrosis in a …

…, P Campbell, DA Fox, D Khanna, SD Larsen… - … of Pharmacology and …, 2014 - ASPET
Systemic sclerosis (SSc), or scleroderma, similar to many fibrotic disorders, lacks effective
therapies. Current trials focus on anti-inflammatory drugs or targeted approaches aimed at …

[HTML][HTML] Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation

…, BD Yestrepsky, RJ Sorenson, M Chen, SD Larsen… - 2012 - journals.plos.org
Staphylococcus aureus is a major human pathogen and one of the more prominent pathogens
causing biofilm related infections in clinic. Antibiotic resistance in S. aureus such as …