User profiles for Scott D. Larsen
Scott D. LarsenResearch Professor of Medicinal Chemistry Verified email at med.umich.edu Cited by 6254 |
Aza Diels-Alder reactions in aqueous solution: cyclocondensation of dienes with simple iminium salts generated under Mannich conditions
SD Larsen, PA Grieco - Journal of the American Chemical Society, 1985 - ACS Publications
Compared to the all-carbon Diels-Alder reaction, the imino variation has received only scant
attention, despite the enormous potential it holds for alkaloid synthesis. 1· 2 The vast …
attention, despite the enormous potential it holds for alkaloid synthesis. 1· 2 The vast …
X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases
Structure-guided design was used to generate a series of noncovalent inhibitors with nanomolar
potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A …
potency against the papain-like protease (PLpro) from the SARS coronavirus (CoV). A …
Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β–induced fibrogenesis in human colonic myofibroblasts
…, ES Rodansky, AJ Haak, SD Larsen… - Inflammatory bowel …, 2014 - academic.oup.com
Background Ras homolog gene family, member A (RhoA)/Rho-associated coiled-coil forming
protein kinase signaling is a key pathway in multiple types of solid organ fibrosis, including …
protein kinase signaling is a key pathway in multiple types of solid organ fibrosis, including …
[HTML][HTML] Redox modification of nuclear actin by MICAL-2 regulates SRF signaling
MR Lundquist, AJ Storaska, TC Liu, SD Larsen… - Cell, 2014 - cell.com
The serum response factor (SRF) binds to coactivators, such as myocardin-related
transcription factor-A (MRTF-A), and mediates gene transcription elicited by diverse signaling …
transcription factor-A (MRTF-A), and mediates gene transcription elicited by diverse signaling …
[HTML][HTML] Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis
Myofibroblasts are crucial to the pathogenesis of tissue fibrosis. Their formation of stress
fibers results in the release of myocardin-related transcription factor (MRTF), a transcriptional …
fibers results in the release of myocardin-related transcription factor (MRTF), a transcriptional …
Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence
…, M Wilson, K Jorgensen-Muga, SD Larsen… - Nature chemical …, 2017 - nature.com
The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system promotes
the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help drive the …
the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help drive the …
[PDF][PDF] A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells
Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy
resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, …
resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, …
Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole …
C Liljebris, SD Larsen, D Ogg, BJ Palazuk… - Journal of medicinal …, 2002 - ACS Publications
Protein tyrosine phosphatases (PTPs) constitute a diverse family of enzymes that, together
with protein tyrosine kinases, control the level of intracellular tyrosine phosphorylation, thus …
with protein tyrosine kinases, control the level of intracellular tyrosine phosphorylation, thus …
Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor–regulated gene transcription prevent fibrosis in a …
Systemic sclerosis (SSc), or scleroderma, similar to many fibrotic disorders, lacks effective
therapies. Current trials focus on anti-inflammatory drugs or targeted approaches aimed at …
therapies. Current trials focus on anti-inflammatory drugs or targeted approaches aimed at …
[HTML][HTML] Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation
…, BD Yestrepsky, RJ Sorenson, M Chen, SD Larsen… - 2012 - journals.plos.org
Staphylococcus aureus is a major human pathogen and one of the more prominent pathogens
causing biofilm related infections in clinic. Antibiotic resistance in S. aureus such as …
causing biofilm related infections in clinic. Antibiotic resistance in S. aureus such as …