Helicobacter pylori moves through mucus by reducing mucin viscoelasticity

…, BS Turner, NH Afdhal, S Keates… - Proceedings of the …, 2009 - National Acad Sciences
The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to
colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic …

Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells

S Keates, YS Hitti, M Upton, CP Kelly - Gastroenterology, 1997 - Elsevier
BACKGROUND & AIMS: Helicobacter pylori adheres to gastric epithelial cells and stimulates
interleukin (IL)-8 production. This may be instrumental in neutrophil infiltration of the gastric …

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

Y Li, HA Rogoff, S Keates, Y Gao… - Proceedings of the …, 2015 - National Acad Sciences
Partial or even complete cancer regression can be achieved in some patients with current
cancer treatments. However, such initial responses are almost always followed by relapse, …

Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag− Helicobacter pylori

S Keates, AC Keates, M Warny, RM Peek… - The Journal of …, 1999 - journals.aai.org
The aim of this study was to determine whether Helicobacter pylori activates mitogen-activated
protein (MAP) kinases in gastric epithelial cells. Infection of AGS cells with an H. pylori cag…

Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea

S Sougioultzis, L Kyne, D Drudy, S Keates, S Maroo… - Gastroenterology, 2005 - Elsevier
Background & aims: Recurrent C difficile-associated diarrhea (CDAD) is associated with a
lack of protective immunity to C difficile toxins. A parenteral C difficile vaccine containing …

Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression

…, KR Bhaskar, X Chen, PM Anton, S Keates… - Biochemical and …, 2006 - Elsevier
Saccharomyces boulardii (Sb) is a non-pathogenic yeast that ameliorates intestinal injury and
inflammation caused by a wide variety of enteric pathogens. We hypothesized that Sb may …

[HTML][HTML] p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

M Warny, AC Keates, S Keates… - The Journal of …, 2000 - Am Soc Clin Investig
Clostridium difficile toxin A causes acute neutrophil infiltration and intestinal mucosal injury.
In cultured cells, toxin A inactivates Rho proteins by monoglucosylation. In monocytes, toxin …

[HTML][HTML] cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells

S Keates, S Sougioultzis, AC Keates, D Zhao… - Journal of Biological …, 2001 - ASBMB
The gastric pathogen Helicobacter pylori is known to activate epithelial cell signaling
pathways that regulate numerous inflammatory response genes. The aim of this study was to …

L-Ascorbic acid and L-galactose are sources for oxalic acid and calcium oxalate in Pistia stratiotes

SE Keates, NM Tarlyn, FA Loewus, VR Franceschi - Phytochemistry, 2000 - Elsevier
Axenic Pistia stratiotes L. plants were pulse-chase labeled with [ 14 C ]oxalic acid, L-[1- 14
C ]ascorbic acid, L-[6- 14 C ]ascorbic acid, D-[1- 14 C ]erythorbic acid, L-[1- 14 C ]galactose, …

IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes

…, S Keates, M Warny, AC Keates… - American Journal …, 1997 - journals.physiology.org
Neutrophil infiltration is central to the pathogenesis of Clostridium difficiletoxin A-induced
enterocolitis. This study examines whether monocyte activation by C. difficile toxins is …