User profiles for Salvatore Cuzzocrea

Salvatore Cuzzocrea

Professore di Farmacologia Università di Messina
Verified email at unime.it
Cited by 64382

Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury

S Cuzzocrea, DP Riley, AP Caputi, D Salvemini - Pharmacological reviews, 2001 - ASPET
A vast amount of circumstantial evidence implicates oxygen-derived free radicals (especially
superoxide and hydroxyl radical) and high-energy oxidants (such as peroxynitrite) as …

[HTML][HTML] Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update

R Siracusa, RD Paola, S Cuzzocrea… - International journal of …, 2021 - mdpi.com
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

…, H Macarthur, TP Misko, MG Currie, S Cuzzocrea… - Science, 1999 - science.org
Many human diseases are associated with the overproduction of oxygen free radicals that
inflict cell damage. A manganese(II) complex with a bis(cyclohexylpyridine)-substituted …

[HTML][HTML] Effects of melatonin treatment in septic newborns

…, M Karbownik, RJ Reiter, DX Tan, S Cuzzocrea… - Pediatric …, 2001 - nature.com
Free radicals have been implicated in the pathogenesis of neonatal sepsis and its complications.
This study was conducted to determine the changes in the clinical status and the serum …

A newly identified role for superoxide in inflammatory pain

ZQ Wang, F Porreca, S Cuzzocrea, K Galen… - … of Pharmacology and …, 2004 - ASPET
Novel classes of pain-relieving molecules are needed to fill the void between nonsteroidal
anti-inflammatory agents and narcotics. Our studies have identified superoxide as a novel …

Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors

V Mollace, C Muscoli, E Masini, S Cuzzocrea… - Pharmacological …, 2005 - ASPET
The biosynthesis and release of nitric oxide (NO) and prostaglandins (PGs) share a number
of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) …

[HTML][HTML] Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

…, I Iavicoli, R Di Paola, A Koverech, S Cuzzocrea… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Modulation of endogenous cellular defense mechanisms represents an innovative
approach to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Antiinflammatory activity of melatonin in central nervous system

E Esposito, S Cuzzocrea - Current neuropharmacology, 2010 - ingentaconnect.com
Melatonin is mainly produced in the mammalian pineal gland during the dark phase. Its
secretion from the pineal gland has been classically associated with circadian and circanual …

Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin

F Fulia, E Gitto, S Cuzzocrea, RJ Reiter… - Journal of pineal …, 2001 - Wiley Online Library
Free radicals have been implicated in the pathogenesis of neonatal asphyxia and its
complications. This study measured a product of lipid peroxidation, malondialdehyde, and the nitrite…

Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size

…, H MOTA‐FILIPE, S Cuzzocrea… - The FASEB …, 2002 - Wiley Online Library
This study was designed to investigate the effects of various chemically distinct activators of
PPAR‐γ and PPAR‐α in a rat model of acute myocardial infarction. Using Northern blot …