DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system
S Caporali, S Falcinelli, G Starace, MT Russo… - Molecular …, 2004 - ASPET
The mammalian mismatch repair (MMR) system has been implicated in activation of the G 2
checkpoint induced by methylating agents. In an attempt to identify the signaling events …
checkpoint induced by methylating agents. In an attempt to identify the signaling events …
[HTML][HTML] Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor
…, E Pagani, T Odorisio, C Schietroma, S Falcinelli… - Journal of investigative …, 2000 - Elsevier
The vascular endothelial growth factor is produced by a large variety of human tumors,
including melanoma, in which it appears to play an important role in the process of tumor-induced …
including melanoma, in which it appears to play an important role in the process of tumor-induced …
The effect of O 6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1, 3-bis (2-chloroethyl …
R Pepponi, G Marra, MP Fuggetta, S Falcinelli… - … of Pharmacology and …, 2003 - ASPET
The prognosis of advanced melanoma is generally poor, because this tumor commonly exhibits
intrinsic or acquired resistance to chemotherapy. In an attempt to identify the underlying …
intrinsic or acquired resistance to chemotherapy. In an attempt to identify the underlying …
Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma
…, E Pagani, N De Luca, S Falcinelli… - Genes …, 2008 - Wiley Online Library
Constitutive activation of the Wnt pathway plays a key role in the development of colorectal
cancer and has also been implicated in the pathogenesis of other malignancies. …
cancer and has also been implicated in the pathogenesis of other malignancies. …
[HTML][HTML] High-frequency microsatellite instability is associated with defective DNA mismatch repair in human melanoma
E Alvino, G Marra, E Pagani, S Falcinelli… - Journal of investigative …, 2002 - Elsevier
Hereditary nonpolyposis colorectal cancers and a steadily increasing number of sporadic
tumors display microsatellite instability. In colorectal tumors, high-frequency microsatellite …
tumors display microsatellite instability. In colorectal tumors, high-frequency microsatellite …
Expression and characterization of Pseudomonas aeruginosa cytochrome c-551 and two site-directed mutants: role of tryptophan 56 in the modulation of redox …
…, I CIABATTI, G ROLLI, S FALCINELLI… - Biochemical …, 1997 - portlandpress.com
The gene coding for Pseudomonas aeruginosacytochrome c-551 was expressed in
Pseudomonas putidaunder aerobic conditions, using two different expression vectors; the more …
Pseudomonas putidaunder aerobic conditions, using two different expression vectors; the more …
Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity
E Pagani, S Falcinelli, R Pepponi… - International …, 2007 - spandidos-publications.com
Hyperthermic isolated limb perfusion (HILP) with L-phenylalanine mustard (L-PAM) represents
an effective treatment for locally advanced melanoma of the limbs. However, regional …
an effective treatment for locally advanced melanoma of the limbs. However, regional …
Processing of GB virus B non-structural proteins in cultured cells requires both NS3 protease and NS4A cofactor
…, E Scarselli, V Amati, S Falcinelli… - Journal of General …, 2000 - microbiologyresearch.org
The identification of antivirals and vaccines against hepatitis C virus (HCV) infection is
hampered by the lack of convenient animal models. The need to develop surrogate models has …
hampered by the lack of convenient animal models. The need to develop surrogate models has …
hMSH3 overexpression and cellular response to cytotoxic anticancer agents
R Pepponi, G Graziani, S Falcinelli, P Vernole… - …, 2001 - academic.oup.com
Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour
cell resistance to O 6 -guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin …
cell resistance to O 6 -guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin …
[CITATION][C] 039; Atri. 2004.“DNA Damage Induced by Temozolomide Signals to Both ATM and ATR: Role of the Mismatch Repair System.”
S Caporali, S Falcinelli, G Starace, MT Russo… - Molecular Pharmacology