Covering: 1988 to 2012 This review presents recommended nomenclature for the biosynthesis
of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly …

Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …

… as a common feature.3, 4 In 2006, Wenzel 5 proposed that the different phenotypes expressed
by … Typically, a patient’s asthma is described in terms of the disease phenotypes. Thus, a …

Asthma is a serious health problem throughout the world. During the past two decades, many
scientific advances have improved our understanding of asthma and ability to manage and …

… year; 4) airflow limitation, ie forced expiratory volume in 1 s (FEV 1 ) <80% predicted (in the
… associated with a reduction in superoxide dismutase and s-nitrosothiol depletion [94, 95]. …

Rationale: The Severe Asthma Research Program cohort includes subjects with persistent
asthma who have undergone detailed phenotypic characterization. Previous univariate …

… Papers identified by the above process were allocated to the relevant Working Group(s)
for joint assessment of the measurement properties, analysis and reporting of the outcome …

Background Moderate-to-severe asthma remains poorly treated. We evaluated the efficacy
and safety of dupilumab (SAR231893/REGN668), a fully human monoclonal antibody to the …

Background Many patients with severe asthma require regular treatment with oral glucocorticoids
despite the use of high-dose inhaled therapy. However, the regular use of systemic …

The mechanisms associated with the development of severe, corticosteroid (CS)-dependent
asthma are poorly understood, but likely heterogenous. It was hypothesized that severe …