How to improve R&D productivity: the pharmaceutical industry's grand challenge
SM Paul, DS Mytelka, CT Dunwiddie… - Nature reviews Drug …, 2010 - nature.com
The pharmaceutical industry is under growing pressure from a range of environmental
issues, including major losses of revenue owing to patent expirations, increasingly cost-…
issues, including major losses of revenue owing to patent expirations, increasingly cost-…
COVID-19 pandemic related supply chain studies: A systematic review
The global spread of the novel coronavirus, also known as the COVID-19 pandemic, has
had a devastating impact on supply chains. Since the pandemic started, scholars have been …
had a devastating impact on supply chains. Since the pandemic started, scholars have been …
Neuroactive steroids
SM Paul, RH Purdy - The FASEB Journal, 1992 - Wiley Online Library
Neuroactive steroids are natural or synthetic steroids that rapidly alter the excitability of neurons
by binding to membrane‐bound receptors such as those for inhibitory and (or) excitatory …
by binding to membrane‐bound receptors such as those for inhibitory and (or) excitatory …
[HTML][HTML] 10-year follow-up of intensive glucose control in type 2 diabetes
RR Holman, SK Paul, MA Bethel… - New England journal …, 2008 - Mass Medical Soc
Background During the United Kingdom Prospective Diabetes Study (UKPDS), patients with
type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of …
type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of …
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
SH Cheng, RJ Gregory, J Marshall, S Paul, DW Souza… - Cell, 1990 - cell.com
… F (lane 6), or endoglycosidase li (lane S). Samples were separated by electrophoresis and
… Following 18 hr of incubation, the cells were washed twice with Dulbeccc’s modified Eagle’s …
… Following 18 hr of incubation, the cells were washed twice with Dulbeccc’s modified Eagle’s …
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3α-hydroxy-5α-dihydroprogesterone
and 3α,5α-tetrahydrodeoxycorticosterone, are potent barbiturate-…
and 3α,5α-tetrahydrodeoxycorticosterone, are potent barbiturate-…
Randomized phase III trial of pemetrexed versus docetaxel in patients with non–small-cell lung cancer previously treated with chemotherapy
…, R Gervais, Shaharyar, C Manegold, S Paul… - Journal of clinical …, 2004 - ascopubs.org
Purpose To compare the efficacy and toxicity of pemetrexed versus docetaxel in patients
with advanced non—small-cell lung cancer (NSCLC) previously treated with chemotherapy. …
with advanced non—small-cell lung cancer (NSCLC) previously treated with chemotherapy. …
[PDF][PDF] Culture media
SK Paul - Language, 1980 - researchgate.net
Hold the plate as though you are going to" paint" the surface of the agar. If you are right-handed,
hold the plate in your left hand, and the inoculating loop in your right-as through you …
hold the plate in your left hand, and the inoculating loop in your right-as through you …
DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?
…, I Strouvalis, S Aloizos, S Kapogiannis… - Clinical infectious …, 2014 - academic.oup.com
Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …
The effect of teriparatide [human parathyroid hormone (1–34)] therapy on bone density in men with osteoporosis
Teriparatide [rhPTH(1–34)] increases bone mineral density and reduces the risk of vertebral
fracture in women. We randomized 437 men with spine or hip bone mineral density more …
fracture in women. We randomized 437 men with spine or hip bone mineral density more …