The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called
tomoxetine or LY139603) has been shown to alleviate symptoms in Attention Deficit/Hyperactivity …

The blockade of serotonin (5-HT) and norepinephrine (NE) transporters in vitro and in vivo
by the dual 5-HT/NE reuptake inhibitors duloxetine and venlafaxine was compared. …

5-Hydroxytryptamine (serotonin) (5-HT) and norepinephrine (NE) are implicated in modulating
descending inhibitory pain pathways in the central nervous system. Duloxetine is a …

… Portions of these data have been previously presented (Hemrick-Luecke et al. 1993) …
Przegalinski et al. 1981; Perry and Fuller 1991; Hemrick-Luecke et al. 1994), although mediation by …

Compounds that block both serotonin (5-HT) and norepinephrine (NE) transporters have been
proposed to have improved antidepressant efficacy. We compared the ability of four dual …

Duloxetine,(+)-N-methyl-3-(1-naphthalenyloxy)-2-thiophenepro-panamine, is an inhibitor of
the serotonin and norepinephnne neuronal transporters(Wong et a!., 1993). In mice, …

Direct-acting serotonin (5-HT) receptor agonists increase serum corticosterone in rats by
activating receptors of the 5-HT 1A or the 5-HT 2A/2C subtypes. While involvement of 5-HT 1A …

LY426965 [(2S)-(+)-1-cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]2-methyl-2-phenyl-1-butanone
monohydrochloride] is a novel compound with high affinity for the cloned human 5…

… The present authors found that a single dose of amphetamine given to iprindole-treated
rats caused a persistent depletion of striatal dopamine at 1 week (Fuller and Hemrick-Luecke, …

Halogenated analogs of the potent norepinephrine (NE) uptake inhibitor, tomoxetine, were
synthesized and their affinities for the serotonin (5HT) and NE uptake sites evaluated. One of …