The basic concepts of environmental toxicology are presented in this publication. The 11
chapters cover: (1) environment: past and present; (2) review of pharmacological concepts; (3) …

The fundamental principles of environmental toxicology are clearly presented here for
university students and professionals in related fields. This book consists of two parts. In the first …

Publisher Summary This chapter describes the preparation of tritiated dihydrofolic acid of
high specific activity. In this method, dihydrofolic acid is formed, by the reduction of folic acid, …

In vitro and in vivo studies have been carried out in mouse and human tumors to investigate
the biochemical and pharmacologic basis for the selectivity of 5-fluorouracil (FUra) action. …

Chromatographic procedures were developed which permit the separation of the monoglutamylfolic
acid derivatives from each other and from their polyglutamyl congeners. Using these …

… Ho, YK, and Zakrzewski, SF Inhibilion of Dihydrofolate ReducÃ-asefrom a Line of Cullured
… Zakrzewski, SF The Mechanism of Binding of Folate Analogues Chem., 240: 2142-2147, …

A precise, specific assay for the 4-amino analogues of folic acid in urine, serum and tissues
has been described. The method is based on the stoichiometric inhibition of the enzyme folic …

The following new 2, 4-diamino-6-methylpyrimidines, 5-cyclohexyimethyl, 5-cyclohexylethyl,
and 5-(2-naphthyl), as well as 2, 6-diaminopurines, 8-adamantyl and 8-adamantylmethyl, …

2, 4-Diamino-6-methylpyrimidines having saturated straight-chain alkyl groups (C3, Cs-C8,
Ciq) in the 5 position were less potent growth inhibitors (IDS0 1.1 to 53 µ) of mouse …

The synthesis and biological activity of eleven new pyrimidines with lipophilic substituents
at the 5 position are described. Two compounds, 5-(l-adamantyl)-2, 4-diaminopyrimidine (3) …