The 5-hydroxytryptamine3 receptor 5-HT3R has been implicated in gut and cardiac motility
and in behavioral disorders. Characteristics of 5-HT3Rs appear to be heterogeneous among …

… (A) Elution profiles by gel filtration chromatography through Sephacryl S-1000SF of … was
in agreement with the results by Sephacryl S-1000SF chromatography described above. The …

Fragile X syndrome is a genetic condition resulting from FMR1 gene mutation that leads to
intellectual disability, autism-like symptoms, and sensory hypersensitivity. Arbaclofen, a GABA…

… Addition of (S)-mandelic acid afforded the (S)-amine salt in a similar manner. This was
recrystallized from MeCN and washed with base to provide the free (S)-amine (3.87 g, 28%): [α] D …

… Next, eight experts in texture studies categorized the 271 term groups into the three texture
attributes proposed by the I nternational S tandard O rganization ( ISO 11036): mechanical …

We examined the pharmacological profile of ramosetron, a 5-HT3-receptor antagonist for
irritable bowel syndrome with diarrhea, comparing it with those of other 5-HT3-receptor …

Background: We newly synthesized YF476 ((R)‐1‐[2,3‐dihydro‐2‐oxo‐1‐pivaloylmethyl‐5‐(2′‐pyridyl)‐1H‐1,4‐benzodiazepin‐3‐yl]‐3‐(3‐methylamino‐phenyl)urea)
as a gastrin/…

… All rabbits in Group S were normal throughout the observation period. Twenty one minutes
of aortic … We think that the very small number of TUNEL-positive neurons detected in Group S …

… We compared the gastrin/CCK-B receptor-blocking properties of this compound with those
of the racemate (mixture of YM022 and its S-form), its enantiomer (S-form), L-365, 260 and Cl-…

In this study, we examined the effects of serotonin (5‐HT) 3 receptor antagonists (5‐HT 3 RAs)
including ramosetron, alosetron, and cilansetron on colonic nociceptive threshold in rats. …