User profiles for Ryan E. Pavlovicz

Ryan Pavlovicz

University of Washington, Ohio State University
Verified email at uw.edu
Cited by 2485

Macromolecular modeling and design in Rosetta: recent methods and frameworks

…, MS Pacella, X Pan, H Park, RE Pavlovicz… - Nature …, 2020 - nature.com
The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …

Curcumin is a potent DNA hypomethylation agent

Z Liu, Z Xie, W Jones, RE Pavlovicz, S Liu, J Yu… - Bioorganic & medicinal …, 2009 - Elsevier
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin
covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was …

[HTML][HTML] ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB

…, CJ Pyle, AC Rudawsky, RE Pavlovicz… - Cell reports, 2013 - cell.com
Activation of the transcription factor NF-κB is essential for innate immune function and
requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc …

Modulation of DNA methylation by a sesquiterpene lactone parthenolide

Z Liu, S Liu, Z Xie, RE Pavlovicz, J Wu, P Chen… - … of Pharmacology and …, 2009 - ASPET
Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …

[PDF][PDF] HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα

…, J Haakenson, C Wang, S Zhang, RE Pavlovicz… - Molecular cell, 2014 - cell.com
MutS protein homolog 2 (MSH2) is a key DNA mismatch repair protein. It forms the MSH2-MSH6
(MutSα) and MSH2-MSH3 (MutSβ) heterodimers, which help to ensure genomic integrity…

Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease

OM Koval, JS Snyder, RM Wolf, RE Pavlovicz, P Glynn… - Circulation, 2012 - Am Heart Assoc
Background— Human gene variants affecting ion channel biophysical activity and/or membrane
localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism …

[HTML][HTML] Efficient consideration of coordinated water molecules improves computational protein-protein and protein-ligand docking discrimination

RE Pavlovicz, H Park, F DiMaio - PLoS Computational Biology, 2020 - journals.plos.org
Highly coordinated water molecules are frequently an integral part of protein-protein and
protein-ligand interfaces. We introduce an updated energy model that efficiently captures the …

Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities

…, L Pan, RE Pavlovicz… - Journal of natural …, 2013 - ACS Publications
Microcos paniculata is a large shrub or small tree that grows in several countries in South and
Southeast Asia. In the present study, three new piperidine alkaloids, microgrewiapines A–…

[HTML][HTML] Autocatalytic cleavage of human γ-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95

MB West, S Wickham, LM Quinalty, RE Pavlovicz… - Journal of Biological …, 2011 - ASBMB
γ-Glutamyl transpeptidase (GGT) is a heterodimeric membrane enzyme that catalyzes the
cleavage of extracellular glutathione and other γ-glutamyl-containing compounds. GGT is …

Structure–activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors

…, B Yi, K Mahasenan, RE Pavlovicz… - Journal of medicinal …, 2011 - ACS Publications
Neuronal nicotinic receptors have been implicated in several diseases and disorders such
as autism, Alzheimer’s disease, Parkinson’s disease, epilepsy, and various forms of addiction…