User profiles for Ryan E. Pavlovicz
Ryan PavloviczUniversity of Washington, Ohio State University Verified email at uw.edu Cited by 2485 |
Macromolecular modeling and design in Rosetta: recent methods and frameworks
The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …
in laboratories worldwide. During two decades of development by a community of …
Curcumin is a potent DNA hypomethylation agent
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin
covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was …
covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was …
[HTML][HTML] ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB
…, CJ Pyle, AC Rudawsky, RE Pavlovicz… - Cell reports, 2013 - cell.com
Activation of the transcription factor NF-κB is essential for innate immune function and
requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc …
requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc …
Modulation of DNA methylation by a sesquiterpene lactone parthenolide
Z Liu, S Liu, Z Xie, RE Pavlovicz, J Wu, P Chen… - … of Pharmacology and …, 2009 - ASPET
Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …
their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA …
[PDF][PDF] HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα
…, J Haakenson, C Wang, S Zhang, RE Pavlovicz… - Molecular cell, 2014 - cell.com
MutS protein homolog 2 (MSH2) is a key DNA mismatch repair protein. It forms the MSH2-MSH6
(MutSα) and MSH2-MSH3 (MutSβ) heterodimers, which help to ensure genomic integrity…
(MutSα) and MSH2-MSH3 (MutSβ) heterodimers, which help to ensure genomic integrity…
Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease
Background— Human gene variants affecting ion channel biophysical activity and/or membrane
localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism …
localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism …
[HTML][HTML] Efficient consideration of coordinated water molecules improves computational protein-protein and protein-ligand docking discrimination
Highly coordinated water molecules are frequently an integral part of protein-protein and
protein-ligand interfaces. We introduce an updated energy model that efficiently captures the …
protein-ligand interfaces. We introduce an updated energy model that efficiently captures the …
Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities
…, L Pan, RE Pavlovicz… - Journal of natural …, 2013 - ACS Publications
Microcos paniculata is a large shrub or small tree that grows in several countries in South and
Southeast Asia. In the present study, three new piperidine alkaloids, microgrewiapines A–…
Southeast Asia. In the present study, three new piperidine alkaloids, microgrewiapines A–…
[HTML][HTML] Autocatalytic cleavage of human γ-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95
MB West, S Wickham, LM Quinalty, RE Pavlovicz… - Journal of Biological …, 2011 - ASBMB
γ-Glutamyl transpeptidase (GGT) is a heterodimeric membrane enzyme that catalyzes the
cleavage of extracellular glutathione and other γ-glutamyl-containing compounds. GGT is …
cleavage of extracellular glutathione and other γ-glutamyl-containing compounds. GGT is …
Structure–activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors
…, B Yi, K Mahasenan, RE Pavlovicz… - Journal of medicinal …, 2011 - ACS Publications
Neuronal nicotinic receptors have been implicated in several diseases and disorders such
as autism, Alzheimer’s disease, Parkinson’s disease, epilepsy, and various forms of addiction…
as autism, Alzheimer’s disease, Parkinson’s disease, epilepsy, and various forms of addiction…