In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy
as part of their treatment, which is one of the most cost-effective cancer treatments. …

Lamotrigine is a novel anticonvulsant drug which also stabilises mood in bipolar illness via
an unknown mechanism. We report the concentration-dependent inhibition of 5-…

In kindling models of epilepsy, the period during which repeated stimulation evokes intensifying
seizures is attributed to an underlying epileptogenic process, and the point at which …

N-[2-[2,3,7,8-tetrahydro-1H-furo(2,3-g)indol-1-yl]ethyl]acetamide (GR196429) is a novel,
nonindolic melatonin receptor agonist. GR196429 had high affinity for human mt 1 (pK i 9.9) …

In this brief review, we present the evidence for the regulation of the mesolimbic dopamine
system by 5-HT 3 and 5-HT 4 receptors. A range of studies show good evidence that 5-HT 3 …

Incorporation of D-Pro9 into substance P related peptides is known to enhance neurokinin
NK-2 receptor agonist potency and selectivity with respect to other neurokinin receptors. We …

GR159897 ((R)-1-[2-(5-fluoro-1H-indol-3-yl)ethyl]-4-methoxy-4-[(phenylsulfinyl)methyl]piperidine)
is a novel, highly potent and selective non-peptide antagonist at tachykinin NK 2 …

The design and synthesis of potent and selective neurokinin NK-2 receptor agonists 12 (GR64349)
and 31 are described, together with structure-activity relationships for related …

The effect of selective neurokinin (NK) receptor agonists on the activity of A9 and A10 dopamine
cells was assessed using extracellular recording. A higher proportion of A10 cells which …

Minaxolone is a potent ligand for the neurosteroid binding site of the GABA A receptor. In
radioligand binding studies to rat brain membranes, minaxolone caused a 69% increase in [ 3 …