Structure− activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

R Lan, Q Liu, P Fan, S Lin, SR Fernando… - Journal of medicinal …, 1999 - ACS Publications
As a potent, specific antagonist for the brain cannabinoid receptor (CB1), the biarylpyrazole
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-…

123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors

SJ Gatley, AN Gifford, ND Volkow, R Lan… - European journal of …, 1996 - Elsevier
We have investigated the binding of 123 I-labeled N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
(AM251), an analog of the …

Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors

SJ Gatley, R Lan, B Pyatt, AN Gifford, ND Volkow… - Life sciences, 1997 - Elsevier
The binding of [ 123 I]AM251 (a radioiodinated analog of the cannabinoid CB1 receptor
antagonist SR141716A) was compared to that of [ 3 H]CP 55,940 in mouse and rat brain …

Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand

R Lan, Q Lu, P Fan, J Gatley, ND Volkow, SR Fernando… - Aaps Pharmsci, 1999 - Springer
In the search for a radioligand capable of imaging cannabinoid CB1 receptors in the living
human brain by SPECT (single photon emission computed tomography), N-(morpholin-4-yl)-1-…

Imaging the brain marijuana receptor: development of a radioligand that binds to cannabinoid CB1 receptors in vivo

SJ Gatley, R Lan, ND Volkow, N Pappas… - Journal of …, 1998 - Wiley Online Library
The major active ingredient of marijuana, (−)‐Δ 9 ‐tetrahydrocannabinol, exerts its psychoactive
effects via binding to cannabinoid CB1 receptors, which are widely distributed in the …

Large receptor reserve for cannabinoid actions in the central nervous system

AN Gifford, M Bruneus, SJ Gatley, R Lan… - … of Pharmacology and …, 1999 - ASPET
The receptor occupancy required to produce cannabinoid effects in the central nervous system
was determined in both a neurochemical and a behavioral assay for cannabinoid actions…

Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression

…, K Ho, B Huck, CCV Jones, R Lan… - ACS Medicinal …, 2023 - ACS Publications
Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition
can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of …

Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal acetylcholine release from rat brain slices

AN Gifford, Y Tang, SJ Gatley, ND Volkow, R Lan… - Neuroscience …, 1997 - Elsevier
The SPECT ligand AM 281, a less lipophilic analog of the cannabinoid receptor antagonist
SR 141716A, robustly potentiated electrically-evoked release of acetylcholine from …

Peanut allergen induces more serious allergic reactions than other allergens involving MAPK signaling pathways

J Wang, R Song, R Lan, M Hao, G Liu, M Liu, S Sun… - Food & Function, 2022 - pubs.rsc.org
There is no universally accepted uniform research to classify the severity of allergic reactions
triggered by different food allergens. We established a food allergy model based on …

Efficient parallel synthesis of macrocyclic peptidomimetics

…, F Bilodeau, M Ramaseshan, N Fortin, R Lan… - Bioorganic & medicinal …, 2008 - Elsevier
A new method for solid phase parallel synthesis of chemically and conformationally diverse
macrocyclic peptidomimetics is reported. A key feature of the method is access to broad …