Vascular smooth muscle cell (VSMC) differentiation is important in understanding vascular
disease; however, no in vitro model is available. Totipotent mouse embryonic stem (ES) cells …

This study characterizes the K + channel(s) underlying charybdotoxin‐sensitive hyperpolarization
of porcine coronary artery endothelium. Two forms of current‐voltage (I/V) relationship …

The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the
primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that pump …

Objectives This study sought to identify subcellular Ca 2+ signals within and among cells
comprising the sinoatrial node (SAN) tissue. Background The current paradigm of SAN impulse …

Background—Hydrogen peroxide (H 2 O 2 ) and reactive oxygen species are implicated in
inflammation, ischemia-reperfusion injury, and atherosclerosis. The role of ion channels has …

Earlier experiments with animal and human arteries have shown that farnesol, a natural 15-carbon
(C 15 ) isoprenoid, is an inhibitor of vasoconstriction (Roullet, J.-B., Xue, H., Chapman…

Background The sinoatrial node (SAN) of the heart produces rhythmic action potentials,
generated via calcium signaling within and among pacemaker cells. Our previous work has …

K + channels and their currents are important in vascular tone regulation and are potential
therapeutic targets; however, K + channels in human coronary artery vascular smooth muscle …

We aimed to determine how age‐associated changes in mechanisms extrinsic and intrinsic
to pacemaker cells relate to basal beating interval variability (BIV) reduction in vivo. Beating …

Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TGAC8)
adapt to an increased cAMP-induced cardiac workload (~ 30% increases in heart …