User profiles for Roque Bort

Roque Bort

Hospital Universitario La Fe
Verified email at gva.es
Cited by 5113

miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and maydownregulate the high affinity cationic amino acid transporter CAT-1

…, MA Buendia, C Xu, WS Mason, T Moloshok, R Bort… - RNA biology, 2004 - Taylor & Francis
These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specificnon-coding
polyadenylated RNA transcribed from the gene hcr. The exact sequence of miR-…

Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity

R Bort, X Ponsoda, R Jover, MJ Gómez-Lechón… - … of Pharmacology and …, 1999 - ASPET
Diclofenac, a 2-arylacetic acid, nonsteroidal anti-inflammatory drug, has been reported to
cause adverse hepatic effects in certain individuals. To discriminate among possible …

[HTML][HTML] Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

R Bort, M Signore, K Tremblay, JPM Barbera… - Developmental …, 2006 - Elsevier
Little is known about the mechanism by which embryonic liver, lung, and pancreas progenitor
cells emerge from the endodermal epithelium to initiate organogenesis. Understanding …

Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas

R Bort, JP Martinez-Barbera, RSP Beddington… - 2004 - journals.biologists.com
In animal development, digestive tissues emerge from different positions of the endoderm
as a result of patterning signals from overlying mesoderm. Although embryonic tissue …

Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways

R Bort, K Macé, A Boobis, MJ Gómez-Lechón… - Biochemical …, 1999 - Elsevier
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with
special focus on the generation of minor hydroxylated metabolites implicated in the …

[HTML][HTML] Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture

RL Gieseck III, NRF Hannan, R Bort, NA Hanley… - PloS one, 2014 - journals.plos.org
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce
the demand for a dwindling number of primary cells used in applications ranging from …

Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved

R Jover, R Bort, MJ Gómez‐Lechón… - The FASEB …, 2002 - Wiley Online Library
The hepatic drug‐metabolizing cytochrome P‐450 (CYP) enzymes are down‐regulated
during inflammation. In vitro studies with hepatocytes have shown that the cytokines released …

[HTML][HTML] Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

J Prieto, M León, X Ponsoda, R Sendra, R Bort… - Nature …, 2016 - nature.com
During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells
switch from oxidative to glycolytic metabolism, a transition associated with profound …

[PDF][PDF] Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus‐mediated antisense targeting

R Jover, R Bort, MJ Gómez‐Lechón, JV Castell - Hepatology, 2001 - Wiley Online Library
Hepatocyte nuclear factor 4 (HNF4) is a member of the nuclear receptor super‐family that
has shown activating effects on particular cytochrome P450 (CYP) promoters from several …

Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent

E Siewert, R Bort, R Kluge, PC Heinrich, J Castell… - Hepatology, 2000 - journals.lww.com
Expression of cytochromes P450 (CYP) is markedly reduced during inflammatory processes.
In vitro studies with hepatocytes have shown that cytokines generated during these …