User profiles for Roque Bort
Roque BortHospital Universitario La Fe Verified email at gva.es Cited by 5113 |
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and maydownregulate the high affinity cationic amino acid transporter CAT-1
These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specificnon-coding
polyadenylated RNA transcribed from the gene hcr. The exact sequence of miR-…
polyadenylated RNA transcribed from the gene hcr. The exact sequence of miR-…
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity
Diclofenac, a 2-arylacetic acid, nonsteroidal anti-inflammatory drug, has been reported to
cause adverse hepatic effects in certain individuals. To discriminate among possible …
cause adverse hepatic effects in certain individuals. To discriminate among possible …
[HTML][HTML] Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
Little is known about the mechanism by which embryonic liver, lung, and pancreas progenitor
cells emerge from the endodermal epithelium to initiate organogenesis. Understanding …
cells emerge from the endodermal epithelium to initiate organogenesis. Understanding …
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
R Bort, JP Martinez-Barbera, RSP Beddington… - 2004 - journals.biologists.com
In animal development, digestive tissues emerge from different positions of the endoderm
as a result of patterning signals from overlying mesoderm. Although embryonic tissue …
as a result of patterning signals from overlying mesoderm. Although embryonic tissue …
Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways
The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with
special focus on the generation of minor hydroxylated metabolites implicated in the …
special focus on the generation of minor hydroxylated metabolites implicated in the …
[HTML][HTML] Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce
the demand for a dwindling number of primary cells used in applications ranging from …
the demand for a dwindling number of primary cells used in applications ranging from …
Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved
The hepatic drug‐metabolizing cytochrome P‐450 (CYP) enzymes are down‐regulated
during inflammation. In vitro studies with hepatocytes have shown that the cytokines released …
during inflammation. In vitro studies with hepatocytes have shown that the cytokines released …
[HTML][HTML] Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells
switch from oxidative to glycolytic metabolism, a transition associated with profound …
switch from oxidative to glycolytic metabolism, a transition associated with profound …
[PDF][PDF] Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus‐mediated antisense targeting
Hepatocyte nuclear factor 4 (HNF4) is a member of the nuclear receptor super‐family that
has shown activating effects on particular cytochrome P450 (CYP) promoters from several …
has shown activating effects on particular cytochrome P450 (CYP) promoters from several …
Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent
Expression of cytochromes P450 (CYP) is markedly reduced during inflammatory processes.
In vitro studies with hepatocytes have shown that cytokines generated during these …
In vitro studies with hepatocytes have shown that cytokines generated during these …