The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in
prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In …

Inheritable bacterial defence systems against phage infection and foreign DNA, termed CRISPR
(clustered regularly interspaced short palindromic repeats), consist of cas protein genes …

The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against
viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli …

Cold induction of cspA, the paradigm Escherichia coli cold-shock gene, is mainly subject to
posttranscriptional control, partly promoted by cis-acting elements of its transcript, whose …

Streptomyces coelicolor GlnR is a global regulator that controls genes involved in nitrogen
metabolism. By genomic screening 10 new GlnR targets were identified, including enzymes …

The Escherichia coli H-NS protein is a nucleoid-associated protein involved in both
transcription regulation and DNA compaction. Each of these processes involves H-NS-mediated …

The adaptation against foreign nucleic acids by the CRISPR–Cas system (Clustered Regularly
Interspaced Short Palindromic Repeats and CRISPR-associated proteins) depends on …

Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor
with 50% effective concentration (EC 50 ) values ranging from 1.4 to 5.0 pM against HCV …

Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase
encoded by the hepatitis C virus (HCV) NS5B gene. Dasabuvir inhibited recombinant NS5B …

The nucleoid-associated protein H-NS is thought to play an essential role in the organization
of bacterial chromatin in Escherichia coli. Homologues, often with very low sequence …