Novel isoquinolinone-derived inhibitors of poly (ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of …
A Chiarugi, E Meli, M Calvani, R Picca, R Baronti… - … of Pharmacology and …, 2003 - ASPET
Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing
the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy …
the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy …
Differential role of poly (ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro
E Meli, M Pangallo, R Picca, R Baronti, F Moroni… - Molecular and Cellular …, 2004 - Elsevier
Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) plays a key
role in the mechanisms responsible for neuronal death. In the present study, we examined …
role in the mechanisms responsible for neuronal death. In the present study, we examined …
The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death
F Moroni, S Attucci, A Cozzi, E Meli, R Picca… - …, 2002 - Elsevier
We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid
(3-MATIDA) by measuring second messenger responses in baby hamster kidney cells …
(3-MATIDA) by measuring second messenger responses in baby hamster kidney cells …
Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo
E Meli, R Picca, S Attucci, A Cozzi, F Peruginelli… - Pharmacology …, 2002 - Elsevier
In order to investigate the involvement of mGlu1 and mGlu5 metabotropic glutamate receptors
in the development of postischemic neuronal death, we examined the effects of selective …
in the development of postischemic neuronal death, we examined the effects of selective …
Group I metabotropic glutamate receptors stimulate the activity of poly (ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures
E Meli, R Baronti, M Pangallo, R Picca, F Moroni… - …, 2005 - Elsevier
Group I metabotropic glutamate (mGlu) receptors (ie mGlu1 and mGlu5) coupled to
phospholipase C have been widely investigated for their possible role in excitotoxic and post-…
phospholipase C have been widely investigated for their possible role in excitotoxic and post-…
[HTML][HTML] Extracellular vesicles and pancreatic cancer: insights on the roles of miRNA, lncRNA, and protein cargos in cancer progression
Pancreatic cancer (PC) is among the most devastating digestive tract cancers worldwide.
This cancer is characterized by poor diagnostic detection, lack of therapy, and difficulty in …
This cancer is characterized by poor diagnostic detection, lack of therapy, and difficulty in …
[HTML][HTML] Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery
Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons of …
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons of …
Pediatric RIFLE for acute kidney injury diagnosis and prognosis for children undergoing cardiac surgery: a single-center prospective observational study
Z Ricci, M Di Nardo, C Iacoella, R Netto, S Picca… - Pediatric …, 2013 - Springer
This study evaluated the performance of the pediatric RIFLE (pRIFLE) score for acute
kidney injury (AKI) diagnosis and prognosis after pediatric cardiac surgery. It was a single-center …
kidney injury (AKI) diagnosis and prognosis after pediatric cardiac surgery. It was a single-center …
Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation
Mitochondrial remodeling is crucial to meet the bioenergetic demand to support muscle
contractile activity during daily tasks and muscle regeneration following injury. A set of …
contractile activity during daily tasks and muscle regeneration following injury. A set of …
[HTML][HTML] Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and …
…, G Morino, B Moro, V Nobili, L Perrone, M Picca… - Italian journal of …, 2018 - Springer
The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity
in Children and Adolescents integrates and updates the previous guidelines to deliver an …
in Children and Adolescents integrates and updates the previous guidelines to deliver an …