Parabens (p-hydroxybenzoate esters) are a group of widely used preservatives in topically
applied cosmetic and pharmaceutical products. Parabens display weak associations with the …

Veliparib (ABT-888) is largely eliminated as parent drug in human urine (70% of the dose).
Renal unbound clearance exceeds glomerular filtration rate, suggesting the involvement of …

A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to
inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor) resistant recombinant HIV-1 …

Administration of delavirdine, an HIV-1 reverse transcriptase inhibitor, to rats or monkeys
resulted in apparent loss of hepatic microsomal CYP3A and delavirdine desalkylation activity. …

The metabolism of delavirdine was examined using liver microsomes from several species
with the aim of comparing metabolite formation among species and characterizing the …

Transient benign unconjugated hyperbilirubinemia has been observed clinically with
several drugs including indinavir, cyclosporine, and rifamycin SV. Genome-wide association …

Considerable effort has been focused over the past decade on the development of the HIV-1
specific nonnucleoside reverse transcriptase inhibitors (NNRTIs), due to their desirable …

The major route of metabolism of the bis(heteroaryl)piperazine (BHAP) class of reverse
transcriptase inhibitors (RTIs), atevirdine and delavirdine, is via oxidative N-dealkylation of the 3-…

Delavirdine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is metabolized primarily
through desalkylation catalyzed by CYP3A4 and CYP2D6 and by pyridine hydroxylation …

Metabolic aromatization of xenobiotics is an unusual reaction with some documented
examples. For instance, the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the …