… We have seen preclinical evidence of synergistic therapeutic effects between an EGFR
TKI and an inhibitor of mammalian target of rapamycin (J. Rich, manuscript in preparation) …

Purpose: Enoticumab (REGN421) is a fully human IgG 1 monoclonal antibody that binds
human Dll4 and disrupts Notch-mediated signaling. The main objectives of this trial were to …

E5564 is a second-generation synthetic analogue of the lipid A component of endotoxin (lipopolysaccharide
[LPS]). The ability of E5564 to block the toxic activity of LPS was assessed …

E5564 (α-d-glucopyranose) is a synthetic antagonist of bacterial endotoxin that has been
shown to completely block human endotoxin response. Low doses of E5564 (0.35-3.5 mg) …

2502 Background: Dll4, a Notch receptor ligand, may have a role in tumor angiogenesis
and is an emerging anticancer target. REGN421 (R) is a fully human IgG 1 mAb that binds …

2516 Background: REGN1400 (R) is a fully human mAb targeting ErbB3. Preclinically, dual
inhibition of ErbB3 and EGFR confers augmented antitumor potency. This first-in-human …

Background Although the effects of propofol on cerebral metabolism have been studied in
animals, these effects have yet to be directly examined in humans. Consequently, we used …

Sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 3 (SERCA3), an isoform of the
intracellular Ca 2+ pump that has been shown to mediate endothelium-dependent relaxation of …

Ig heavy chain (IgH) class switch recombination (CSR) in B lymphocytes switches IgH
constant regions to change antibody functions. CSR is initiated by DNA double-strand breaks (…

Electron paramagnetic resonance (EPR) imaging is an emerging modality that can detect
and localize paramagnetic molecular probes (so-called spin probes) in vivo. We previously …