The role of apoptosis in acetaminophen (AAP)-induced hepatic injury was investigated. Six
hours after AAP administration to BALB/c mice, a significant loss of hepatic mitochondrial …

The effects, over periods from 3 days to 9 months of administration, of diets containing di-2-ethylhexyl
phthalate are very similar to those observed in rats administered diets containing …

The effects of phthalate esters of branched chain alcohols, typified by di-(2-ethylhexyl)phthalate
(DEHP) differ from those of esters of straight chain alcohols typified by di-n-hexyl …

Groups of male and groups of female Wistar albino rats were administered diets containing
sufficient di(2-ethylhexyl) phthalate (DEHP) to ensure intakes of either 1000, 200, or 50 mg/kg…

Abstract Treatment of rats for periods of 3 months or longer with the hypolipidaemic drugs
clofibrate and fenofibrate or with the plasticiser di-(2-ethylhexyl) phthalate causes alterations in …

The mechanism of Fas antigen‐induced hepatocyte apoptosis was investigated. Using a
monoclonal antibody directed against the Fas antigen, apoptosis was induced in freshly …

This study compares changes in the livers of rats treated with di(2-ethylhexyl) phthalate (DEHP)
and its straight-chain analogs di(n-hexyl) phthalate (DnHP) and di(n-octyl phthalate (…

Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but
not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and …

Morphological changes in bile duct lining cells precede morphological changes in hepatocytes
in rats treated with 300 mg/kg body wt of α-naphthylisothiocyanate (ANIT). Four hours …

The mild analgesic drug acetaminophen (AAP) induces severe hepatic injury when taken at
excessive doses. Recent evidence shows that the initial form of damage is through apoptosis…