Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

SG Kinsey, JZ Long, ST O'Neal, RA Abdullah… - … of Pharmacology and …, 2009 - ASPET
Direct-acting cannabinoid receptor agonists are well known to reduce hyperalgesic responses
and allodynia after nerve injury, although their psychoactive side effects have damped …

[PDF][PDF] Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum

…, JT Morra, CS Lansink, R Cachope, RA Abdullah… - Neuron, 2012 - cell.com
Transient increases in nucleus accumbens (NAc) dopamine concentration are observed
when animals are presented with motivationally salient stimuli and are theorized to energize …

The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice

L Booker, SG Kinsey, RA Abdullah… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Inflammatory pain presents a problem of clinical relevance
and often elicits allodynia, a condition in which non‐noxious stimuli are perceived as painful…

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice

JE Schlosburg, BLA Carlson, D Ramesh, RA Abdullah… - The AAPS journal, 2009 - Springer
Abstinence symptoms in cannabis-dependent individuals are believed to contribute to the
maintenance of regular marijuana use. However, there are currently no medications approved …

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice

…, JE Schlosburg, RA Owens, RA Abdullah… - … of Pharmacology and …, 2011 - ASPET
Δ 9 -Tetrahydrocannbinol (THC), the primary active constituent of Cannabis sativa, has long
been known to reduce opioid withdrawal symptoms. Although THC produces most of its …

[HTML][HTML] FAAH−/− mice display differential tolerance, dependence, and cannabinoid receptor adaptation after Δ9-tetrahydrocannabinol and anandamide …

…, JE Schlosburg, BF Cravatt, RA Abdullah… - …, 2010 - nature.com
Repeated administration of Δ 9-tetrahydrocannabinol (THC), the primary psychoactive
constituent of Cannabis sativa, induces profound tolerance that correlates with desensitization …

The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking …

JL Wilkerson, S Ghosh, M Mustafa, RA Abdullah… - …, 2017 - Elsevier
Although opioids are highly efficacious analgesics, their abuse potential and other untoward
side effects diminish their therapeutic utility. The addition of non-opioid analgesics offers a …

The selective monoacylglycerol lipase inhibitor MJN110 produces opioid-sparing effects in a mouse neuropathic pain model

…, TW Grim, MA Mustafa, RA Abdullah… - … of Pharmacology and …, 2016 - ASPET
Serious clinical liabilities associated with the prescription of opiates for pain control include
constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized …

Cannabinoid receptor–interacting protein 1a modulates CB1 receptor signaling and regulation

…, JRS McVoy, KW Sayers, JL Poklis, RA Abdullah… - Molecular …, 2015 - ASPET
Cannabinoid CB 1 receptors (CB 1 Rs) mediate the presynaptic effects of endocannabinoids
in the central nervous system (CNS) and most behavioral effects of exogenous …

Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice

LE Wise, KA Long, RA Abdullah, JZ Long… - ACS chemical …, 2012 - ACS Publications
Acute administration of Δ 9 -tetrahydrocannabinol (THC) or exposure to marijuana smoke
impairs short-term spatial memory in water maze tasks through a CB 1 receptor mechanism of …