Biochemical, electrophysiological, and pharmacological evidence supporting a role for
cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has …

Several reviewers have summarized and critically evaluated the growing literature on age-related
changes in human memory (see, eg, Craik, 1977; Flicker et al., 1985; Fozard, 1985; …

The pace of nigrostriatal degeneration, both with regards to striatal denervation and loss of
melanin and tyrosine hydroxylase-positive neurons, is poorly understood especially early in …

Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost. —RT …

Background In an open-label phase 1 trial, gene delivery of the trophic factor neurturin via
an adeno-associated type-2 vector (AAV2) was well tolerated and seemed to improve motor …

Background There is an urgent need for therapies that slow or reverse the progression of
Parkinson's disease (PD). Neurotrophic factors can improve the function of degenerating …

The authors discuss the cholinergic hypothesis of geriatric memory dysfunction, which
proposes the following:(1) Significant, functional disturbances in cholinergic activity occur in the …

The occurrence of multiple tumors in an organ heralds a rapidly fatal course. Although
intravascular administration may deliver oncolytic viruses/vectors to each of these tumors, its …

Two separate experiments were conducted to evaluate the effects of the anti-cholinergic
scopolamine on primate visual discrimination and short-term memory (STM). In the first …

Objective We tested the hypothesis that gene delivery of the trophic factor neurturin could
preserve motor function and protect nigrostriatal circuitry in hemiparkinsonian monkeys. …