A colony of 26 chimpanzees given a fruit and vegetable diet of very low Na and high K intake
were maintained in long–standing, socially stable small groups for three years. Half of them …

This review examines the recent progress in the field of angiotensin receptors. Multiplicity of
these receptors was demonstrated initially on the basis of pharmacologic differences and …

The renin-angiotensin-aldosterone system plays an important role in blood pressure regulation
by influencing salt-water homeostasis and vascular tone. The purpose of the present …

Background— Addition of up to 15.0 g/d salt to the diet of chimpanzees caused large rises in
blood pressure, which reversed when the added salt was removed. Effects of more modest …

… BAUD L, PEREZ J, FRIEDLANDER G, ARDAILLOU R: Tumor necrosis factor stimulates
prostaglandin production and cyclic AMP levels in rat cultured mesangial cells. FEBS Lett 239:50…

ENZYMATIC PATHWAYS OF PRODUCTION OF ANGIOTENSIN II FRAGMENTS Ang II can
be hydrolyzed both at its N terminal and C terminal ends. Its precursor, the decapeptide Ang I…

This review discusses the metabolism of arachidonic acid to prostaglandins (PG) and other
metabolites and the site of physiological action of these products along the nephron. …

Human recombinant tumor necrosis factor-α (TNF) was found to stimulate the production of
prostaglandins (PG) by cultured rat mesangial cells. This effect was demonstrable from 6 h, …

Hypertension is often associated with the development of nephroangio- and glomerulo-sclerosis.
This pathophysiological process is due to increased extracellular matrix protein, …

Raymond Ardaillou Page 1 Active fragments of angiotensin II: enzymatic pathways of
synthesis and biological effects Raymond Ardaillou Angiotensin (Ang) ll is not the only active …