3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones:  Synthesis and Pharmacological Activity of Neuroactive Steroids with High Affinity for GABAA Receptors

RB Upasani, KC Yang, M Acosta-Burruel… - Journal of medicinal …, 1997 - ACS Publications
Neuroactive steroids that allosterically modulate GABA A receptors have potential uses as
anticonvulsants, anxiolytics, and sedative−hypnotic agents. Recently, a series of pregnanes …

Substituted 3β-phenylethynyl derivatives of 3α-hydroxy-5α-pregnan-20-one: remarkably potent neuroactive steroid modulators of γ-aminobutyric acidA receptors

…, RM Woodward, RB Carter, RB Upasani - … of Pharmacology and …, 1998 - ASPET
Neuroactive steroids are positive allosteric modulators of γ-aminobutyric acid A (GABA A )
receptor complexes. Synthetic modification generally does not increase neuroactive steroid …

Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles, pyrazoles and imidazoles as NR1A/2B antagonists

…, JC Huang, CS Konkoy, RB Upasani… - Bioorganic & medicinal …, 1999 - Elsevier
4-Benzyl-1-[4-(1H -imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent
antagonist of the NR1a/2B subtype of the NMDA receptor. When dosed orally, this compound …

Structure-activity relationship for a series of 2-substituted 1, 2, 3, 4-tetrahydro-9H-pyrido [3, 4-b] indoles: Potent subtype-selective inhibitors of N-methyl-d-aspartate …

…, ER Whittemore, RM Woodward, RB Upasani… - Bioorganic & medicinal …, 1999 - Elsevier
… Transfer of the hydroxy group to the Aring (see Table 2 for the A, B numbering convention)
results in 24 and a fourfold drop in potency. Removal of the hydroxy group gives 25 and …

Studies related to alkylations of enolate anions of 1, 4‐benzodiazepinones

RI Fryer, JC Pinto, RB Upasani - Journal of heterocyclic …, 1993 - Wiley Online Library
Abstract Treatment of 1,4‐benzodiazepinone derivatives with a Wittig‐Horner reagent, led
to the desired carboncarbon bond formation at the amide carbonyl carbon atom in …

Polyphenoxy Radicals: Synthesis and Homo-Polymerization of 2-(3, 5-Dl-t-Butyl-4-Hydroxyphenyl) Isobutyl Methacrylate

RB Upasani, LY Chiang, DP Goshorn - MRS Online Proceedings …, 1989 - cambridge.org
We evaluated the chemical stability of various polyphenoxy radicals prepared through the
modified synthetic methods. The monomeric 3,5-di-t-butyl-4-hydroxyphenyl derivatized olefins …

Synthesis of Bulk High Spin Density Charge Transfer Complexes for Organic Magnets

LY Chiang, RB Upasani, DP Goshorn… - MRS Online …, 1989 - cambridge.org
We describe a synthetic approach to the preparation of high spin density organic solid as a
probe to organic ferromagnetism utilizing an external doping process to achieve a molecular …

[PDF][PDF] POLYPHENOXY RADICALS: SYNTHESIS AND HOMO-POLYMERIZATION OF 2-(3, 5-DI-t-BUTYL-4-HYDROXYPHENYL) ISOBUTYL METHACRYLATE

BU RAVINDRA, Y LONG - Long Y. Chiang Paul M. Chaikin - researchgate.net
We evaluated the chemical stability of various polyphenoxy radicals prepared through the
modified synthetic methods. The monomeric 3, 5-di-t-butyl-4-hydroxyphenyl derivatized olefins …

[CITATION][C] Studies in cyandethylation and related reactions

RB Upasani - shodhganga.inflibnet.ac.in
Shodhganga@INFLIBNET: Studies in cyandethylation and related reactions Skip
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Analgesic and Antiinflammatory Activity of Amarwel extracts on experimentally induce pain and inflammation on animals

…, RB Saudagar, CD Upasani - Research Journal of …, 2014 - indianjournals.com
Materials and Methods Petroleum ether extract, methanol extract, and aqueous extracts of
Cuscuta reflexa (PECR, MECR, and AECR respectively) at three dose levels of 50, 200 and …