User profiles for Ratanesh Kumar Seth
 | Ratanesh Kumar Seth, M. Sc., Ph. D.Environmental Health Sciences, University of South Carolina, Columbia, SC, USA Verified email at mailbox.sc.edu Cited by 1651 |
Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis
Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) is the common pathophysiological
process resulting from chronic liver inflammation and oxidative stress. Although significant …
process resulting from chronic liver inflammation and oxidative stress. Although significant …
Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are
hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular …
hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular …
Synthesis of highly substituted 2-perfluoroalkyl quinolines by electrophilic iodocyclization of perfluoroalkyl propargyl imines/amines
A series of highly substituted 2-perfluoroalkyl-3-iodoquinolines are prepared by two different
methods in good to excellent yields under mild reaction conditions. The first method …
methods in good to excellent yields under mild reaction conditions. The first method …
Environmental toxin–linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice
Obesity is associated with strong risks of development of chronic inflammatory liver disease
and metabolic syndrome following a second hit. This study tests the hypothesis that free …
and metabolic syndrome following a second hit. This study tests the hypothesis that free …
Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War …
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical
and pharmaceutical exposures during the war. Since an increased number of veterans …
and pharmaceutical exposures during the war. Since an increased number of veterans …
[HTML][HTML] NADPH oxidase–derived peroxynitrite drives inflammation in mice and human nonalcoholic steatohepatitis via TLR4-lipid raft recruitment
…, D Dattaroy, S Pourhoseini, RK Seth… - The American journal of …, 2015 - Elsevier
The molecular events that link NADPH oxidase activation and the induction of Toll-like
receptor (TLR)-4 recruitment into hepatic lipid rafts in nonalcoholic steatohepatitis (NASH) are …
receptor (TLR)-4 recruitment into hepatic lipid rafts in nonalcoholic steatohepatitis (NASH) are …
[HTML][HTML] High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty …
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to
the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact …
the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact …
Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation
Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis
(NASH), finding an efficient treatment regimen for it remains elusive. The present study …
(NASH), finding an efficient treatment regimen for it remains elusive. The present study …
Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity
Today's developed world faces a major public health challenge in the rise in the obese
population and the increased incidence in fatty liver disease. There is a strong association …
population and the increased incidence in fatty liver disease. There is a strong association …
Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 …
SsnB previously showed a promising role to lessen liver inflammation observed in a mouse
model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its …
model of NAFLD. Since NAFLD can progress to fibrosis, studies were designed to unravel its …