Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of myocyte
dysfunction and the ability of reactive oxygen species (ROS) to induce the intracellular Ca 2…

In view of the critical role of sarcoplasmic reticular (SR) Ca 2+ release and the Ca 2+ pump
in cardiac contraction-relaxation, this study was undertaken to assess the status of SR …

In view of the depressed sarcoplasmic reticulum (SR) Ca 2+ -pump and Ca 2+ -release activities
in the diabetic heart and the critical role of phosphorylation in regulating the SR function…

Although Ca 2+ /calmodulin-dependent protein kinase-II (CaMK) is known to phosphorylate
different Ca 2+ cycling proteins in the cardiac sarcoplasmic reticulum (SR) and regulate its …

The sarcoplasmic reticulum (SR) is a major player in maintaining cardiac function, as it is
intimately involved in the regulation of Ca 2+ -movements on a beat-to-beat basis. SR …

Background: It has been shown that serotonin (5-hydroxytryptamine, 5-HT) is involved in
exacerbating vascular abnormalities; however, its role in mediating changes in cardiac function …

We have previously shown that ischemic preconditioning (IP) improves cardiac performance
and sarcoplasmic reticulum (SR) function in hearts subjected to ischemia-reperfusion (I/R). …

Although β-adrenoceptor (β-AR) blockers are used for the treatment of ischemic heart disease,
the mechanisms of their beneficial actions have not been fully elucidated. In view of the …

Although ischemia reperfusion has been shown to depress gene expression of the
sarcoplasmic reticulum (SR) proteins, such as the ryanodine receptor, Ca 2+ ‐pump ATPase, …

Although the involvement of serotonin in exacerbating vascular abnormalities in ischemic
heart disease has been established, its role in mediating changes in cardiac function due to …