Purpose: Brain metastases of breast cancer appear to be increasing in incidence, confer
significant morbidity, and threaten to compromise gains made in systemic chemotherapy. The …

Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …

Purpose We evaluated the uptake of angiopep-2 paclitaxel conjugate, ANG1005, into brain
and brain metastases of breast cancer in rodents. Most anticancer drugs show poor delivery …

Purpose Lapatinib, a small molecule EGFR/HER2 inhibitor, partially inhibits the outgrowth
of HER2+ brain metastases in preclinical models and in a subset of CNS lesions in clinical …

Brain metastases are a common cause of death in stage IV metastatic melanoma. Dabrafenib
is a BRAF (gene encoding serine/threonine-protein kinase B-Raf) inhibitor that has been …

Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast
cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist …

Vemurafenib [N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide(PLX4032)]
is a novel small-molecule BRAF inhibitor, recently …

The objective of this study was to quantitatively examine the protein expression of relevant
transporters and other proteins in the brain capillary endothelial cells isolated from wild-type …

The importance of the blood–brain barrier in preventing effective pharmacotherapy of
glioblastoma has been controversial. The controversy stems from the fact that vascular endothelial …

Brain (central nervous system; CNS) metastases pose a life-threatening problem for women
with advanced metastatic breast cancer. It has recently been shown that the vasculature …