Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs)
at the growing front sprout by forming filopodia. Those tip cells are not exposed to …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Existing vascular endothelial growth factor–oriented antiangiogenic approaches are known
for their high potency. However, significant side effects associated with their use drive the …

Protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) is a transmembrane tyrosine
phosphatase (TP) expressed in endothelial cells and required for stimulation of cell migration by …

The small GTPase RhoA participates in actin and microtubule machinery, cell migration and
invasion, gene expression, vesicular trafficking and cell cycle, and its dysregulation is a …

Lymphangiogenesis, the formation of lymphatic vessels from preexisting ones, is an important
process in wound-healing physiology. Deregulation of lymphangiogenesis and lymphatic …

Cutaneous wound healing is an intricate and multifaceted process. Despite these complexities,
the distinct phases of wound healing provide a unique opportunity to evaluate the roles …

Lymphangiogenesis is an essential physiological process but also a determining factor in
vascular-related pathological conditions. Angiopoietin-2 (Ang2) plays an important role in …

Anti-angiogenic approaches have significantly advanced the treatment of vascular-related
pathologies. The ephemeral outcome and known side effects of the current vascular …