Thiopurine methyltransferase (TPMT) catalyzes thiopurine S-methylation, an important
metabolic pathway for drugs such as 6-mercaptopurine. Erythrocyte (RBC) TPMT activity was …

Background: The efficacy of tamoxifen therapy for the treatment of breast cancer varies widely
among individuals. Plasma concentrations of the active tamoxifen metabolite endoxifen …

There is substantial variability among individual patients in the responses to pharmaceutical
agents. Among the sources of variation in response are genetic differences in the enzymes …

Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such
as L-DOPA. A common genetic polymorphism in humans is associated with a three-to-…

Metabolomics is the study of metabolism at the global level. This rapidly developing new
discipline has important potential implications for pharmacologic science. The concept that …

This article reviews recent pharmacogenetic and pharmacogenomic advances and
discusses how such advances are reflected in the labeling of drugs.

Although the potential for genomics to contribute to clinical care has long been anticipated,
the pace of defining the risks and benefits of incorporating genomic findings into medical …

Azathioprine therapy can cause acute myelosuppression. Toxicity is in part caused by the
incorporation of azathioprine‐derived 6‐thioguanine nucleotides (6‐TGN) into …

Background Tamoxifen is biotransformed to the potent anti-estrogen, endoxifen, by the
cytochrome P450 (CYP) 2D6 enzyme. CYP2D6 genetic variation and inhibitors of the enzyme …

▪ Abstract Methyl conjugation is an important pathway in the biotransformation of many
exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase …