Radioiodination techniques for small organic molecules

RH Seevers, RE Counsell - Chemical reviews, 1982 - ACS Publications
Radioactive isotopes of iodine have proven to be very useful for labeling both large and small
molecules. A great many methods have been published for attaching radioiodine to target …

Lipoproteins as potential site-specific delivery systems for diagnostic and therapeutic agents

RE Counsell, RC Pohland - Journal of medicinal chemistry, 1982 - ACS Publications
Ever since the pioneering studies of Paul Ehrlich, 1 medicinal chemists and pharmacologists
have been in-terested in the site-specific delivery of drugs—the “magic bullet” concept. This …

Synthesis and structure− activity relationship effects on the tumor avidity of radioiodinated phospholipid ether analogues

…, MD Gross, JP Weichert, RE Counsell - Journal of medicinal …, 2006 - ACS Publications
Radioiodinated phospholipid ether analogues have shown a remarkable ability to selectively
accumulate in a variety of human and animal tumors in xenograft and spontaneous tumor …

Tumor localizing agents. IX. Radioiodinated cholesterol

RE Counsell, VV Ranade, RJ Blair, WH Beierwaltes… - Steroids, 1970 - Elsevier
19-Iodocholesterol- 125 I was synthesized for study as a possible agent for photoscanning
the adrenal gland and associated tumors. In contrast to previous radioiodinated steroids, it …

[PDF][PDF] Radiolabeled cholesterol as an adrenal scanning agent

…, LM Lieberman, CM Boyd, RE Counsell… - Journal of Nuclear …, 1971 - Soc Nuclear Med
MATERIALS AND METHODS Fifty-eight mongrel dogs weighing 7— 13 kg were injected
intravenously with 14C-and 125I-labeled cholesterol in ethanol solution. Five to 10@ Ciof †…

Polyiodinated triglyceride analogs as potential computed tomography imaging agents for the liver

…, T Chou, SW Schwendner, RE Counsell - Journal of medicinal …, 1995 - ACS Publications
A series of glyceryl 2-oleoyl l, 3-bis [co-(3-amino-2, 4, 6-triiodophenyl)] alkanoates was
synthesized, radioiodinated with iodine-125, emulsified, and evaluated for theirability to …

Lipid-based blood-pool CT imaging of the liver

…, FT Lee Jr, MA Longino, SG Chosy, RE Counsell - Academic …, 1998 - Elsevier
RATIONALE AND OBJECTIVES.: We have recently developed an iodinated lipid-based
contrast agent capable of residing in the blood pool for extended periods of time relative to …

Adrenal proteins bound by a reactive intermediate of mitotane

W Cai, RE Counsell, DE Schteingart… - Cancer chemotherapy …, 1997 - Springer
Purpose: Mitotane (o,p′-DDD), is the only adrenolytic agent available for the treatment of
adrenocortical carcinoma. Previous studies have shown that mitotane covalently binds to …

Radioiodination via isotope exchange in pivalic acid

…, ME Van Dort, MP Groziak, RE Counsell - International Journal of …, 1986 - Elsevier
A variety of benzoic and aryl aliphatic mono and polyiodinated acids and esters (sterol,
triglyceride) were radioiodinated in 55–99% radiochemical yield by isotope exchange with Na …

Bovine adrenal cortex transformations of mitotane [1-(2-chlorophenyl)-1-(4-chlorophenyl)-2, 2-dichloroethane; o, p′-DDD] and its p, p′-and m, p′-isomers

W Cai, R Benitez, RE Counsell, T Djanegara… - Biochemical …, 1995 - Elsevier
The adrenalytic activity of mitotane (o,p′-DDD) has made it useful in the treatment of
adrenocortical carcinoma and Cushing's syndrome. In support of a study to develop mitotane …