We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)
pyridine], a novel orally active agent that selectively inhibits …

The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during
apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation. The predominant site of …

… Zamboni … J.; Young, RN; Zamboni, R.; Boyce, S.; Rupniak, N.; Patrick, D.; Riendeau, DJ
Pharmacol. Exp. Ther. … Chan, C.; Boyce, S.; Brideau, C.; Ford-Hutchinson, AW; Gordon, R.; …

Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to
address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and …

The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in
inflammation and that COX-1 is the major isoform responsible for the production of prostaglandins (…

Several treatments have been suggested to correct dentofacial abnormalities, including
orthognathic surgery. The aim of the present systematic review was to assess the impact of …

DFU (5,5‐dimethyl‐3‐(3‐fluorophenyl)‐4‐(4‐methylsulphonyl)phenyl‐2(5H)‐furanone) was
identified as a novel orally active and highly selective cyclo‐oxygenase‐2 (COX‐2) inhibitor. …

Herein we trace links between biochemical pathways, pathogenesis, and metabolic diseases
to set the stage for new therapeutic advances. Cellular and acellular microorganisms …

A general approach to the synthesis of a new class of LTD 4 antagonists is presented. The
key diarylpropane framework was prepared by Claisen−Schmidt condensation and selective …

Several molecules inhibit axonal growth cones and may account for the failure of central
nervous system regeneration, including myelin proteins and various chondroitan sulfate …