Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions

…, RB Caldwell, J Huang, RW Caldwell - Journal of the American …, 1999 - jacc.org
Objectives. We tested the hypothesis that pravastatin (PRA) activates endothelial nitric oxide
synthase (eNOS). Background. Pravastatin has been found to have clinical benefits beyond …

Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives

RB Caldwell, M Bartoli, MA Behzadian… - Diabetes/metabolism …, 2003 - Wiley Online Library
Retinal neovascularization and macular edema are central features of diabetic retinopathy,
the major cause of blindness in the developed world. Current treatments are limited in their …

Arginase: a multifaceted enzyme important in health and disease

RW Caldwell, PC Rodriguez, HA Toque… - Physiological …, 2018 - journals.physiology.org
The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase: an old enzyme with new tricks

RB Caldwell, HA Toque, SP Narayanan… - Trends in …, 2015 - cell.com
Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The
former provides protection against NH 3 ; the latter serves to stimulate cell growth and other …

Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress

RB Caldwell, M Bartoli, MA Behzadian… - Current drug …, 2005 - ingentaconnect.com
Retinal neovascularization and macular edema are central features of diabetic retinopathy,
a major cause of blindness in working age adults. The currently established treatment for …

Therapeutic use of citrulline in cardiovascular disease

…, DH Platt, RB Caldwell, RW Caldwell - Cardiovascular drug …, 2006 - Wiley Online Library
L‐citrulline is the natural precursor of L‐arginine, substrate for nitric oxide synthase (NOS)
in the production of NO. Supplemental administration L‐arginine has been shown to be …

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

…, AM Alkilany, RB Caldwell, RW Caldwell - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE NO produced by endothelial NOS is needed for normal
vascular function. During diabetes, aging and hypertension, elevated levels of arginase can …

[HTML][HTML] Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy

…, T Lemtalsi, RW Caldwell, RB Caldwell - … & visual science, 2008 - arvojournals.org
purpose. Inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase (statins) reduce signs of
diabetic retinopathy in diabetic patients and animals. Indirect clinical evidence supports the …

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

…, AD Verin, RB Caldwell, RW Caldwell - … of Physiology-Cell …, 2011 - journals.physiology.org
Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing NO …

The role of RhoA/Rho kinase pathway in endothelial dysfunction

G Yang, RB Caldwell, L Yao, MJ Romero… - Journal of …, 2010 - Elsevier
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes
clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK…