Vascular endothelial growth factor in eye disease

…, A Madan, RB Caldwell, M Bartoli, RW Caldwell… - Progress in retinal and …, 2008 - Elsevier
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions

…, RB Caldwell, J Huang, RW Caldwell - Journal of the American …, 1999 - jacc.org
… William Caldwell … William Caldwell … Kaesemeyer WH, Abou-Mohamed G., Crute TD and
Caldwell RW : "Nitrates supplemented with l-arginine for the reversal and treatment of nitrate …

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

…, M Bartoli, RB Caldwell, RW Caldwell - Circulation …, 2008 - Am Heart Assoc
Increases in arginase activity have been reported in a variety of disease conditions
characterized by vascular dysfunction. Arginase competes with NO synthase for their common …

Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives

…, DH Platt, RW Caldwell - Diabetes/metabolism …, 2003 - Wiley Online Library
Retinal neovascularization and macular edema are central features of diabetic retinopathy,
the major cause of blindness in the developed world. Current treatments are limited in their …

Arginase: a multifaceted enzyme important in health and disease

RW Caldwell, PC Rodriguez, HA Toque… - Physiological …, 2018 - journals.physiology.org
The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase: an old enzyme with new tricks

…, HA Toque, SP Narayanan, RW Caldwell - Trends in …, 2015 - cell.com
Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The
former provides protection against NH 3 ; the latter serves to stimulate cell growth and other …

Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress

…, DH Platt, GI Liou, RW Caldwell - Current drug …, 2005 - ingentaconnect.com
Retinal neovascularization and macular edema are central features of diabetic retinopathy,
a major cause of blindness in working age adults. The currently established treatment for …

Neuroprotective effect of (−) Δ9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite

…, NJ Tsai, P Roon, RB Caldwell, RW Caldwell… - The American journal of …, 2003 - Elsevier
In glaucoma, the increased release of glutamate is the major cause of retinal ganglion cell
death. Cannabinoids have been demonstrated to protect neuron cultures from glutamate-…

Therapeutic use of citrulline in cardiovascular disease

…, DH Platt, RB Caldwell, RW Caldwell - Cardiovascular drug …, 2006 - Wiley Online Library
L‐citrulline is the natural precursor of L‐arginine, substrate for nitric oxide synthase (NOS)
in the production of NO. Supplemental administration L‐arginine has been shown to be …

[PDF][PDF] Pharmacology of the enantiomers of threo-methylphenidate.

KS Patrick, RW Caldwell, RM Ferris… - … of Pharmacology and …, 1987 - researchgate.net
(MPH) was evaluated in the rat to assess the relative contribution of each isomer to central
and peripheral actions of the racemuc drug. Fractional recrystallization of binaphthyl …