1, 4-Benzothiazine (1, 4-BT) derivatives have been reported to exhibit a wide range of
pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-…

… free hydroxyl group, favor the binding of the R isomer over the S. Since both isomers adopt
… binding energy of the R isomer is likely due to a better conformational strain energy of (R)-3 (…

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro
antibacterial activity was evaluated. The 1, 4-benzothiazine intermediates, which by Gould-Jacobs …

We reviewed the studies on the in vitro and in vivo antifungal activity of 1, 4-benzothiazine
azole derivatives (1, 4-BT). A number of different 1, 4-BT have been tested for anti-Candida …

We previously reported that azole 1,4-benzothiazine derivatives have appreciable anti-Candida
activity. In this study, we synthesized 1,4-benzoxazine analogues and examined their …

… , being shifted from 1-S to 1-R. This behavior is explained by the accommodation of the alkyl/…
BT and BO rings to adopt a slightly different pose that is best fitted by the 1-R stereoisomers. …

A series of azole derivatives of 1,4-benzothiazine 7–14 was synthesized and evaluated for
the in vitro and in vivo activity against Candida albicans. Secondary alcohol 10 and its ether …

… As far as it concerns compound 13, docking experiments reveal that the S isomer fits
better the enzymatic site along channel 2 then the R isomer. The adopted binding pose of …

As a part of a program to develop novel antifungal agents, new compounds which incorporate
the 1,4-benzothiazine moiety into the structure of ketoconazole (KTZ) were prepared. …

A new and efficient procedure for the transformation of α-diazo-β-hydroxy esters into the
corresponding β-keto esters, which involves the use of Rh2 (OAc) 4, is described.