… in tadpoles (18), and 2-butanol does not exhibit stereoselective inhibition of N-methyl-Daspartate
(NMDA) receptors or potentiation of y-aminobutyric A (GABA,) receptors (RW Peoples, …

Despite the fact that ethanol is one of the most widely used psychoactive agents, the mechanisms
and sites of action by which it modifies brain functions are only now being elucidated. …

… The initial proposal was that the native Chamorro people of Guam were exposed to BMAA
through the consumption of cycad seeds containing BMAA. However, it was determined that …

… On the other hand, due to the urgency of generating disease-modifying therapeutics to
treat people suffering from AD, we believe that the present data provide novel insights into …

… [22] Lovinger, DM and Peoples, RW, Actions of alcohols and other sedative/hypnotic
compounds on cation channels associated with glutamate and 5-HT 3 receptors. In C. Ailing, I. …

Glycine receptors (GlyRs), together with GABA A and nicotinic acetylcholine (ACh) receptors,
form part of the ligand-activated ion channel superfamily and regulate the excitability of the …

Background: The beta-amyloid peptide (Aβ) involved in Alzheimer’s disease (AD) has been
described to associate/aggregate on the cell surface disrupting the membrane through pore …

The evidence presented above indicates that GABA-and glutamate-activated ion channels
are molecular sites of alcohol and anesthetic action. In view of the important role that these …

The mechanism by which amyloid-β (Aβ) produces brain dysfunction in patients with Alzheimer's
disease is largely unknown. According to previous studies, Aβ might share perforating …

The current understanding about ethanol effects on the ligand-gated ion channel (LGIC)
superfamily has been restricted to identify potential binding sites within transmembrane (TM) …