Asthma is a common respiratory disorder characterized by recurrent episodes of coughing,
wheezing and breathlessness. Although environmental factors such as allergen exposure …

Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits
lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines, IL-1β, IL-6, IL-8, …

The enzymatic oxidation of arachidonic acid has been shown to yield potent pathological
agents by two major pathways. Those of the prostaglandin (PG) pathway, particularly PGE 2 , …

• An explanation of chronic thyroiditis in man was sought in observations made on rabbits,
dogs, guinea pigs, and human subjects. The rabbits received injections of saline extracts of …

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation
and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective …

… Author links open overlay panel RW Egan , J Paxton , FA Kuehl Jr … EGAN,* JOHN PAXTON,
AND FREDERICK A. KUEHL, JR. From the Merck Institute for Therapeutic … Egan RW …

Upon addition of LPS to human PBMCs, IL-1 beta, IL-6, and TNF-alpha were released in the
culture media in a time-dependent manner. Cytokine release began 2 h after LPS addition …

… SK, Adams GKIII, Kreutner W, Egan RW, Chapman RW. Effects of an antibody to Interleukln-S
In … Kung, and RW Egan. 1990. Anaphylactic challenge causes eosinophil accumulation in …

Hypotonic stimulation induces airway constriction in normal and asthmatic airways. However,
the osmolarity sensor in the airway has not been characterized. TRPV4 (also known as VR-…

The type 4 phosphodiesterase (PDE4) is the predominant PDE isozyme in various leukocytes
and plays a key role in the regulation of inflammatory cell activation. There are four PDE4 …