User profiles for R Tsutsumi

Ryouhei Tsutsumi

Kitasato University
Verified email at kitasato-u.ac.jp
Cited by 4692

GnRH pulsatility, the pituitary response and reproductive dysfunction

R Tsutsumi, NJG Webster - Endocrine journal, 2009 - jstage.jst.go.jp
… on the GnRh-R. estradiol also augments GnRH-R expression and sensitivity to GnRH [19]. …
Model for regulation of signaling by the GnRh-R in response to tonic or pulsatile GnRh. Tonic …

SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein

H Higashi, R Tsutsumi, S Muto, T Sugiyama, T Azuma… - Science, 2002 - science.org
Helicobacter pylori CagA protein is associated with severe gastritis and gastric carcinoma.
CagA is injected from the attached Helicobacter pylori into host cells and undergoes tyrosine …

Dynamic protein palmitoylation in cellular signaling

T Iwanaga, R Tsutsumi, J Noritake, Y Fukata… - Progress in lipid …, 2009 - Elsevier
Protein S-palmitoylation, the most common lipid modification with the 16-carbon fatty acid
palmitate, provides an important mechanism for regulating protein trafficking and function. The …

Discovery of protein-palmitoylating enzymes

R Tsutsumi, Y Fukata, M Fukata - Pflügers Archiv-European Journal of …, 2008 - Springer
Posttranslational modification provides proteins with additional function and regulatory
control beyond genomic information, allowing cells to maintain homeostasis and respond to …

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

H Higashi, R Tsutsumi, A Fujita… - Proceedings of the …, 2002 - National Acad Sciences
Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA + H. pylori strains
are more virulent than cagA − strains and are associated with gastric carcinoma. The cagA …

Stromal cell–derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

T Kitaori, H Ito, EM Schwarz, R Tsutsumi… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Stromal cell–derived factor 1 (SDF‐1; CXCL12/pre–B cell growth‐stimulating
factor) is a dominant chemokine in bone marrow and is known to be involved in inflammatory …

[HTML][HTML] Attenuation of Helicobacter pylori CagA· SHP-2 signaling by interaction between CagA and C-terminal Src kinase

R Tsutsumi, H Higashi, M Higuchi, M Okada… - Journal of Biological …, 2003 - ASBMB
Helicobacter pylori (H. pylori) is a causative agent of gastric diseases ranging from gastritis
to cancer. The CagA protein is the product of thecagA gene carried among virulent H. …

[HTML][HTML] Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

H Higashi, A Nakaya, R Tsutsumi, K Yokoyama… - Journal of Biological …, 2004 - ASBMB
The CagA protein of Helicobacter pylori, which is injected from the bacteria into bacteria-attached
gastric epithelial cells, is associated with gastric carcinoma. CagA is tyrosine-…

Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors

S Kawabata, R Tsutsumi, A Kohara, T Yamaguchi… - Nature, 1996 - nature.com
STIMULATION of two metabotropic glutamate-receptor subtypes, mGluRl and mGluRS, triggers
the release of Ca 2+ from intra-cellular stores through the inositol-(1,4,5) trisphosphate (…

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA

R Tsutsumi, A Takahashi, T Azuma… - … and cellular biology, 2006 - Am Soc Microbiol
Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis,
peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated …