in a superior intercostal space in individuals with high clinical suspicion (aborted sudden
cardiac death victims, family members of patients with Brugada syndrome) may also disclose …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD) is
mediated by β adrenergic receptor (βAR) activation, which increases the slow outward …

… all these missense mutations resulted in loss of function, and the reduction in the
potassium-channel current was remedied by the application of the phospholipase inhibitor ONO-RS-…

Every year, ∼450,000 individuals in the United States die suddenly of cardiac arrhythmia.
We identified a variant of the cardiac sodium channel gene SCN5A that is associated with …

1. Under the influence of strophantidin, Purkinje fibres exhibit transient inward current (TI)
which contributes to arrhythmogenic activity. Voltage‐clamp experiments were carried out to …

… To test the hypothesis that the intrauterine death observed in Ryr2 RS/RS mice was due to
… in Ryr2 RS/RS mice, then S107 might prevent the excess Ryr2 RS/RS mortality observed at …

… PEG 400 has no effect on Ca channel current at a concentration 50 times higher than that
used in the present study (Kass, 1982). Nicardipine and verapamil were dissolved in distilled …

A-kinase anchoring proteins (AKAPs) recruit signaling molecules and present them to
downstream targets to achieve efficient spatial and temporal control of their phosphorylation state. …

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has
provided a wealth of information about fundamental mechanisms underlying human cardiac …