[HTML][HTML] Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma

…, DP Petrylak, R Laliberte… - … England Journal of …, 2020 - Mass Medical Soc
Background Platinum-based chemotherapy is standard-of-care first-line treatment for advanced
urothelial carcinoma. However, progression-free survival and overall survival are limited …

ATP acts as an agonist to promote stimulus-induced secretion of IL-1β and IL-18 in human blood

DG Perregaux, P McNiff, R Laliberte… - The Journal of …, 2000 - journals.aai.org
Cultured monocytes and macrophages stimulated with LPS produce large quantities of proIL-1β,
but release little mature cytokine to the medium. The efficiency at which the procytokine …

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors

DG Perregaux, P McNiff, R Laliberte, N Hawryluk… - … of Pharmacology and …, 2001 - ASPET
Lipopolysaccharide (LPS)-activated monocytes and macrophages produce large quantities
of pro-interleukin (IL)-1β but externalize little mature cytokine. Efficient post-translational …

Effect of mitochondrial viability and metabolism on technetium-99m-sestamibi myocardial retention

P Crane, R Laliberté, S Heminway, M Thoolen… - European Journal of …, 1993 - Springer
This study investigated the mechanism of myocardial retention of technetium-99m-sestamibi.
99m Tc-sestamibi was injected intravenously into guinea pigs, and the myocardium was …

[HTML][HTML] ATP treatment of human monocytes promotes caspase-1 maturation and externalization

RE Laliberte, J Eggler, CA Gabel - Journal of Biological Chemistry, 1999 - ASBMB
Mechanisms that regulate conversion of prointerleukin-1β (pro-IL-1β) to its mature form by
the cysteine protease caspase-1 are not well understood. In this study, we demonstrate that …

Lower airways remodeling in nonasthmatic subjects with allergic rhinitis.

J Chakir, M Laviolette, M Boutet, R Laliberte… - … ; a journal of technical …, 1996 - europepmc.org
We analyzed by immunohistochemistry the distribution of types I, II, III, IV, V, and VII collagens,
laminin, and fibronectin in the bronchial biopsy specimens of nonasthmatic subjects with …

CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer

MA Morse, DA Bradley, T Keler, RJ Laliberte… - Expert review of …, 2011 - Taylor & Francis
Cancer vaccines have demonstrated clinical benefit, however greater efficacy could be
achieved by enhancing their immunogenicity. Owing to cancer vaccines depending on uptake …

[HTML][HTML] Human monocyte interleukin-1β posttranslational processing: evidence of a volume-regulated response

DG Perregaux, RE Laliberte, CA Gabel - Journal of Biological Chemistry, 1996 - ASBMB
Interleukin (IL)-1β produced by monocytes and macrophages is not released via the normal
secretory apparatus, and prior to its release, this cytokine must be proteolytically processed …

Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors

…, TA Mays, G Chambers, A Ma, J Wang, R Laliberte… - Clinical cancer …, 2014 - AACR
Purpose: This first-in-human phase I study evaluated dose-limiting toxicities (DLT) and defined
a phase II recommended dose (RD) for CUDC-101, a multitargeted inhibitor of HDACs, …

[HTML][HTML] Avelumab first-line maintenance for advanced urothelial carcinoma: results from the JAVELIN Bladder 100 trial after≥ 2 years of follow-up

…, J Wang, B Huang, RJ Laliberte… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Clinical trials frequently include multiple end points that mature at different times. The initial
report, typically based on the primary end point, may be published when key planned …