Drug-induced long QT syndrome (diLQTS) and congenital LQTS (cLQTS) share many
features, and both syndromes can result in life-threatening torsades de pointes (TdP). Our …

… Pinney SP, Koller BS, Franz MR, Woosley RL. Terfenadine increases the QT interval in …
Funck-Brentano C, Silberstein DJ, Roden DM, Wood AJJ, Woosley RL. Mechanism of D-sotalol …

… diphenhydramine’s effects on the QT interval in isolated perfused feline hearts (RL Woosley
… Chen Y, Woosley RL. Ketoconazole blocks potassium currents in feline heart. Circulation 88:…

Objectives and Methods. —To gain insight into possible mechanisms of and predisposing
factors for torsades de pointes during terfenadine therapy, spontaneous reports in the US …

Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in
blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin …

Quinidine therapy is one of the most common causes of the acquired long QT syndrome
and torsade de pointes. In reviewing clinical data in 24 patients with the quinidine-associated …

Background Sex hormones are known to exert direct and indirect effects on cardiovascular
function, but their effects on cardiac repolarization have not been elucidated. The …

ContextWomen have a higher incidence of torsades de pointes than men, but it is not
known if the risk of drug-induced torsades de pointes varies during the menstrual cycle.…

To investigate the relation between acetylator phenotype and the development of
procainamide-induced lupus, we determined the rate of development of antinuclear antibodies in 20 …

We have evaluated the ability of various opioid agonists, including methadone, l-α-acetylmethadol
(LAAM), fentanyl, meperidine, codeine, morphine, and buprenorphine, to block the …