Infants and young children with acute onset of wheezing and reduced respiratory airflows
are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie …

SARS coronavirus (SARS-CoV) emerged in 2002 as an important cause of severe lower
respiratory tract infection in humans and in vitro models of the lung are needed to elucidate …

The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition
molecules mediate host immunity to various pathogenic stimuli. However, in vivo …

The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection,
but its physiologic functions have not been described. In nonpolarized cells, CAR localized …

All coronaviruses known to have recently emerged as human pathogens probably originated
in bats 1 . Here we use a single experimental platform based on immunodeficient mice …

Gene therapy for cystic fibrosis (CF) lung disease requires efficient gene transfer to airway
epithelial cells after intralumenal delivery. Most gene transfer vectors so far tested have not …

Airway mucus forms the structural basis of the local innate immune defense mechanism. It is
an integrated, active, viscoelastic gel matrix evolved to protect the exposed lung from …

… alveolar cells for this length of time in vitro does not result in cultures that are significantly
different in terms of differentiation or morphology from cultures grown for 3 to 5 days (RJ Pickles…

Outbreaks from zoonotic sources represent a threat to both human disease as well as the
global economy. Despite a wealth of metagenomics studies, methods to leverage these …

Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid (PCL),
to facilitate the mucus clearance component of lung defense. Studies under standard (…