Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant …
…, V Chu, CL Heran, SR Morgan, RG Bentley… - Bioorganic & medicinal …, 2002 - Elsevier
Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …
culminating in the identification of 9c (FXV673), a potent and selective factor Xa inhibitor with …
Novel cAMP PDE III inhibitors: 1, 6-naphthyridin-2 (1H)-ones
…, ED Pagani, DC Bode, RG Bentley… - Journal of medicinal …, 1992 - ACS Publications
Two series of medorinone (3) analogs were prepared by modifications at C (2) and C (5). The
C (2)-series was prepared from 2-chloro-5-methyl-l, 6-naphthyridine (4) by replacement of …
C (2)-series was prepared from 2-chloro-5-methyl-l, 6-naphthyridine (4) by replacement of …
Phosphodiesterase isozyme inhibition, activation of the cAMP system, and positive inotropy mediated by milrinone in isolated guinea pig cardiac muscle
…, PC Canniff, RE Lepore, RG Bentley… - Journal of …, 1989 - journals.lww.com
The purpose of the present study was to examine the interrelationships among phosphodiesterase
(PDE) isozyme inhibition, cAMP formation, activation of cAMP-dependent protein …
(PDE) isozyme inhibition, cAMP formation, activation of cAMP-dependent protein …
Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease
…, DJ Behm, N Aiyar, K Maniscalco, RG Bentley… - … of Pharmacology and …, 2009 - ASPET
The evidence is compelling for a role of inflammation in cardiovascular diseases; however,
the chronic use of anti-inflammatory drugs for these indications has been disappointing. The …
the chronic use of anti-inflammatory drugs for these indications has been disappointing. The …
[PDF][PDF] Gender differences in the impact of incarceration on the children and families of drug offenders
SF Sharp, ST Marcus-Mendoza, RG Bentley… - Journal of the …, 1997 - academia.edu
Oklahoma’s prison population is one of the largest per capita in the country, and its female
per capita incarceration rate is the highest in the nation. Drug offenders are the biggest …
per capita incarceration rate is the highest in the nation. Drug offenders are the biggest …
Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle
PJ Silver, LT Hamel, MH Perrone, RG Bentley… - European journal of …, 1988 - Elsevier
Phosphodiesterase isozymes were isolated by diethylaminoethyl ether (DEAE) column
chromatography from cardiac muscle (canine, guinea pig), vascular (canine and guinea pig aortic…
chromatography from cardiac muscle (canine, guinea pig), vascular (canine and guinea pig aortic…
Novel and potent adenosine 3', 5'-cyclic phosphate phosphodiesterase III inhibitors: thiazolo [4, 5-b][1, 6] naphthyridin-2-ones
…, DC Bode, ED Pagani, RG Bentley… - Journal of medicinal …, 1995 - ACS Publications
The transformation of 3-bromo-l, 6-naphthyridin-2 (lfD-ones 8 to thiazolo [4, 5-6][l, 6]
naphthyridin-2 (LH)-ones 12 resulted in a 2—9-fold increasein cAMP phosphodiesterase (PDE) III …
naphthyridin-2 (LH)-ones 12 resulted in a 2—9-fold increasein cAMP phosphodiesterase (PDE) III …
SB 234551 selective ETA receptor antagonism: Perfusion/Diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection
…, RE Haimbach, TR Schaeffer, RG Bentley… - Experimental …, 2008 - Elsevier
Mismatches between tissue perfusion-weighted imaging (PWI; an index of blood flow deficit)
and cellular diffusion-weighted imaging (DWI; an index of tissue injury) provide information …
and cellular diffusion-weighted imaging (DWI; an index of tissue injury) provide information …
Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization
…, CL Heran, SR Morgan, RG Bentley… - Journal of medicinal …, 1999 - ACS Publications
Sulfonamidopyrrolidinones were previously disclosed as a selective class of factor Xa (fXa)
inhibitors, culminating in the identification of RPR120844 as a potent member with efficacy in …
inhibitors, culminating in the identification of RPR120844 as a potent member with efficacy in …
Inhibition of the low Km cyclic AMP phosphodiesterase and activation of the cyclic AMP system in vascular smooth muscle by milrinone.
…, B O'connor, BM Lemp, LT Hamel, RG Bentley… - … of Pharmacology and …, 1988 - ASPET
The purposes of the present study were to quantitate the effects of the cardiotonic/vasodilator
milrinone on phosphodiesterase (PDE) isozymes isolated from vascular (aortic) smooth …
milrinone on phosphodiesterase (PDE) isozymes isolated from vascular (aortic) smooth …