Each of three harmala alkaloids, harmine, harmaline, and harmalol, decreased heart rate
and increased pulse pressure, peak aortic flow, and myocardial contractile force in intact …

We determined the relative rank orders of anticholinergic potencies of 10 antihistamines in
two functional bioassays: (1) an in vitro assay measuring inhibition of carbachol-induced …

A method was developed for extracting and measuring nanogram quantities of prostaglandin
E2 (PGE2) from carrageenan-induced abscess in the rat. PGE2 concentration, quantitated …

… Inc., Palo Alto, CA, USA) and a Shimadzu RF-551 Fluorescence HPLC Monitor (Shimadzu
Corp., Kyoto, … Our laboratory (Loss and Orzechowski, 1998) has demonstrated that continuous …

Isolated lung strips of guinea pigs were examined as an in vitro model for assessing the direct
effect of β-adrenergic drugs at the level of peripheral airways. Changes in intrinsic tone of …

Systemic and local immunological responses of rats sensitized with either M. butyricumor
native type II collagen have been evaloatod. In rats exhibiting adjuvant-induced arthritis no …

The bi‐weekly, intraperitoneal administration of sodium cobaltinitrite in doses of 50, 60, and
70 mg./Kg. in mice subjected to the MCD 50 of methylcholanthrene resulted in a reduction of …

Three antihistaminic agents—diphenhydramine, doxylamine, and methapyrilene—alone
and in combination with epinephrine, were examined for their effectiveness against adjuvant …

Significant toxicologic and pharmacologic interactions occurred between chlorpheniramine
maleate and 25% vv ethanol at several dosage combinations. Conditions of both …

A radioisotopic method, originally developed for measuring the cellular response in delayed
hypersensitivity lesions in mice, has been evaluated in adjuvant arthritic rats. Focal …