Effects of perfluorodecanoic acid (PFDA, 20–80 mg/kg, ip) on the androgenic status of
sexually mature male rats were investigated 7 days after treatment. PFDA decreased plasma …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) decreases plasma androgen concentrations in
male rats, without increasing plasma luteinizing hormone (LH) concentrations. If plasma LH …

… concentrations by altering the regulation of LH secretion (Bookstaff et al., 1990). Specifically,
… Freezing and storage at -76C did not affect GnRH receptor binding characteristics (Bookstaff…

Experiments were conducted to test the hypothesis that acute TCDD toxicity is associated
with pituitary hypofunction. Sexually mature male Sprague‐Dawley rats were given graded …

Rats pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 10 micrograms/kg) are
supersensitive to the edemagenic effects of carrageenan and dextran as indicated by the …

The absorption, distribution, and excretion of radiolabeled ethyl oleate (EO) was studied in
Sprague–Dawley rats after a single, peroral dose of 1.7 or 3.4g/kg body weight and was …

The effects of doxylamine (as the succinate salt) on microsomal enzyme activity and serum
thyroid hormone levels were examined in B6C3F1 mice following dietary exposure for 7 or 15 …

Safety assessment of over-the-counter (OTC) drug products frequently involves ongoing
evaluation as new data become available on the active ingredients used in these products. This …

The purpose of this study was to determine the safety of ethyl oleate (EO) in a 91-day feeding
study in Sprague–Dawley rats. EO was mixed into AIN-93G purified diet at levels of 0, 3.3, …

Abstract Effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) on the responsiveness of male
rats to hormones were investigated. TCDD treatment of postpubescent rats increased the …