Losartan is a 4-chloro-5-hydroxymethylimidazole derivative that is a potent and highly selective
angiotensin II receptor antagonist. Losartan is metabolized in vivo in rats, monkeys, and …

… 1) is a nonsteroidal anti-inflammatory drug that is widely used for the treatment of a variety
of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and acute muscle aches …

The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal
hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three …

Recently, it was shown that diclofenac was metabolized in rats to reactive benzoquinone
imines via cytochrome P450-catalyzed oxidation. These metabolites also were detected in …

Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have
been found to be anorexigenic and to stimulate erectile activity. We report the design and …

Finasteride is employed in treatment of benign prostatic hyperplasia in man, where its target
enzyme is steroid 5α-reductase. It is a novel, potent mechanism-based inhibitor of the …

Nortricyclane, methylcyclopropane, and bicyclo [2.1. 0] pentane have been used to probe the
catalytic mechanism of microsomal cytochromeP-450. Nortricyclane is oxidized by rat liver …

Raloxifene is a selective estrogen receptor modulator which is effective in the treatment of
osteoporosis in postmenopausal women. We report herein that cytochrome P450 (P450)3A4 …

Cytochromes P450 (CYP) 3A4 is the most abundant human hepatic CYP isoform catalyzing
the metabolism of approximately 50percent of therapeutic agents. In addition to inhibition or …

The metabolism of diclofenac has been reported to produce reactive benzoquinone imine
intermediates. We describe the identification of mercapturic acid derivatives of diclofenac in …