An effective immune response involves the specific recognition of and elimination of an
infectious organism at multiple levels. In this context DNA immunization can present functional …

ICRF-187 was tested for cardioprotective activity in doxorubicin-treated mice and guinea
pigs. Pretreatment with ip ICRF-187 caused a significant decrease in the indicence of iv …

Discussion 5, 8-ADT has a complex profile of effects as demonstrated by the data presented.
The apparent conflict in results be-tween the effect on spontaneous motor activity and the …

MATERIALS AND METHODS Mouse study.-Female Cox ICR mice (Laboratory Animal
Supply, Indianapolis, IN) were quarantined for 7 days and weighed 18-22 g at the start of the …

Studies to determine the extent of local tissue penetration of topically applied trolamine [ 14
C]salicylate were conducted in domestic pigs. The preparation was applied onto a 100-cm 2 …

1-n-Butyryl-4-cinnamylpiperazine hydrochloride, AP-237, is a new analgesic that has been
reported in both Japan and the United States to have good analgesic activity in animals and …

… General Rat Screening-All compounds were tested and the results were analyzed according
to the methods described by Malone and Carrano (13). Nonfasted albino rats (180-210 g.) …

A novel staining technique has been devised that permits a cartilage examination of unskinned
fetal rats that have been previously processed for skeletal examination with alizarin red S…

In rats norcaperatic acid produced delayed onset, dose‐related effects of mydriasis, skeletal
muscle weakness, and central nervous system depression similar to those induced by its …

Aspirin was administered by oral gavage to 25 gravid Sprague‐Dawley rats on gestation
day 10, as a single dose of 500 mg/kg, in a concentration of 50 mg/ml. The aspirin was …