This study investigated the effects of rimonabant (SR141716), an antagonist of the cannabinoid
receptor type 1 (CB1), on obesity-associated hepatic steatosis and related features of …

To elucidate how the proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor alirocumab
modulates lipoprotein(a) [Lp(a)] plasma levels, the authors performed a series of Lp(a) …

Mitochondrial dysfunction has been identified as a possible early event in ischemia-reperfusion
damage. The peripheral benzodiazepine receptor, a mitochondrial inner membrane …

Rationale: Impaired myocardial relaxation is an intractable feature of several heart failure (HF)
causes. In human HF, detyrosinated microtubules stiffen cardiomyocytes and impair …

The role of angiotensin receptor subtypes 1 and 2 was assessed on neointima formation
after injury in rat carotid artery. The effects of angiotensin converting enzyme inhibition by …

NOTCH plays a pivotal role during normal development and in congenital disorders and
cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block …

Recent advances in basic and clinical research have identified Rho kinase as an important
target potentially implicated in a variety of cardiovascular diseases. Rho kinase is a …

The calcium channel blocker diltiazem lowers heart rate in man and this property probably
contributes to its clinical effectiveness in ischaemic heart disease and hypertension. This …

Recent data suggest that angiotensin II AT 1 receptor antagonists may be beneficial in the
treatment of atherosclerosis. To clarify how AT 1 receptor antagonists reduce atherosclerosis, …

Aims Despite improvements in patient identification and management, heart failure (HF)
remains a major public health burden and an important clinical challenge. A variety of animal …