Glucans are (1–3)-β-d-linked polymers of glucose that are produced as fungal cell wall
constituents and are also released into the extracellular milieu. Glucans modulate immune …

Glucans are immunomodulatory carbohydrates found in the cell walls of fungi and certain
bacteria. We examined the pharmacokinetics of three water-soluble glucans (glucan …

Glucans are structurally diverse fungal biopolymers that stimulate innate immunity and are
fungal pathogen-associated molecular patterns. Dectin-1 is a C-type lectin-like pattern …

Glucans are cell wall constituents of fungi and bacteria that bind to pattern recognition
receptors and modulate innate immunity, in part, by macrophage activation. We used surface …

Candida auris is among the most important emerging fungal pathogens, yet mechanistic
insights into its immune recognition and control are lacking. Here, we integrate transcriptional …

Glucan phosphate, a water-soluble, chemically defined (1-->3)-beta-D-glucan biologic
response modifier, has been reported to exert antisepsis activity and accelerate wound healing. …

Many primary human tumors and tumor cell lines highly express human L-type amino acid
transporter 1 (hLAT1); cancerous cells in vivo are strongly linked to LAT1 expression. …

Ligation of Dectin-1 by fungal glucans elicits a Th17 response that is necessary for clearing
many fungal pathogens. Laminarin is a (1→ 3, 1→ 6)-β-glucan that is widely reported to be a …

Fungal cell wall glucans nonspecifically stimulate various aspects of innate immunity.
Glucans are thought to mediate their effects via interaction with membrane receptors on …

Previous reports showed that nontypeable Haemophilus influenzae (NTHi) reside in
macrophage-like cells in human adenoid tissue. This study investigated the ability of nonopsonized …