Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model
SW Hayward, PC Haughney, MA Rosen, KM Greulich… - Differentiation, 1998 - Elsevier
Tissue recombinants composed of adult human prostatic epithelium (hPrE) and rat urogenital
sinus mesenchyme (rUGM) were grafted beneath the renal capsule of athymic rodent hosts…
sinus mesenchyme (rUGM) were grafted beneath the renal capsule of athymic rodent hosts…
A human prostatic epithelial model of hormonal carcinogenesis
Y Wang, D Sudilovsky, B Zhang, PC Haughney… - Cancer research, 2001 - AACR
The effects of stromal and hormonal environment on the immortalized but nontumorigenic
human prostatic epithelial cell line BPH-1 were investigated in an in vivo model. BPH-1 cells …
human prostatic epithelial cell line BPH-1 were investigated in an in vivo model. BPH-1 cells …
Complement inhibition in cynomolgus monkeys by anti–factor D antigen-binding fragment for the treatment of an advanced form of dry age-related macular …
…, M van Lookeren Campagne, PC Haughney… - … of Pharmacology and …, 2014 - ASPET
Anti–factor D (AFD; FCFD4514S, lampalizumab) is a humanized IgG Fab fragment directed
against factor D (fD), a rate-limiting serine protease in the alternative complement pathway (…
against factor D (fD), a rate-limiting serine protease in the alternative complement pathway (…
The rat prostatic epithelial cell line NRP‐152 can differentiate in vivo in response to its stromal environment
SW Hayward, PC Haughney, ES Lopes… - The …, 1999 - Wiley Online Library
BACKGROUND The clonally derived rat prostatic epithelial cell line NRP‐152 was examined
to determine its ability to differentiate in a tissue recombination model. METHODS NRP‐…
to determine its ability to differentiate in a tissue recombination model. METHODS NRP‐…
Differential gene expression of transforming growth factors alpha and beta, epidermal growth factor, keratinocyte growth factor and their receptors in fetal and adult …
R Dahiya, C Lee, PC Haughney, R Chui, R Ho, G Deng - Urology, 1996 - Elsevier
OBJECTIVES: Recent studies have shown that growth factors may play a role in the etiology
of benign prostatic hyperplasia (BPH) and prostatic carcinoma. Several growth factors have …
of benign prostatic hyperplasia (BPH) and prostatic carcinoma. Several growth factors have …
Species-specific detection of growth factor gene expression in developing murine prostatic tissue
PC Haughney, SW Hayward, R Dahiya… - Biology of …, 1998 - academic.oup.com
The aim of the present study was to develop a method by which the expression of paracrine
signaling molecules could be localized to either epithelial or stromal cells of developing …
signaling molecules could be localized to either epithelial or stromal cells of developing …
Terms and techniques: New approach to hot-start polymerase chain reaction using Taq DNA polymerase antibody
R Dahiya, G Deng, K Chen, PC Haughney… - … Oncology: Seminars and …, 1995 - Elsevier
The purpose of this study was to optimize the conditions for polymerase chain reaction (PCR).
The most common problem with conventional PCR is the presence of nonspecific …
The most common problem with conventional PCR is the presence of nonspecific …
SGN-2FF: a small-molecule inhibitor of fucosylation modulates immune cell activity in preclinical models and demonstrates pharmacodynamic activity in early phase 1 …
…, RA Heiser, W Zeng, SM Hengel, J Wall, PC Haughney… - Cancer Research, 2018 - AACR
SGN-2FF, an orally bioavailable small molecule inhibitor of glycoprotein fucosylation,
demonstrates encouraging preclinical antitumor activity in mouse models with suggested multiple …
demonstrates encouraging preclinical antitumor activity in mouse models with suggested multiple …
Regression of LNCaP human prostate tumor xenografts in athymic nude mice by 13-cis-retinoic acid and androgen ablation.
R Dahiya, DY Zhang, RJ Ho, PC Haughney… - Biochemistry and …, 1995 - europepmc.org
The present study was designed to investigate the effects of 13-cis-retinoic acid (13-cis-RA)(100
micrograms/mouse/day) and androgen ablation (castration) alone and in combination …
micrograms/mouse/day) and androgen ablation (castration) alone and in combination …
Evaluation of the relationship between evolocumab 140 mg every two weeks and 420 mg monthly dosing regimens
…, JP Gibbs, J Legg, MG Emery, PC Haughney… - Circulation, 2014 - Am Heart Assoc
Introduction: Understanding the pharmacodynamic profile of a therapeutic monoclonal antibody
against PCSK9 is critical for selecting optimal dosing regimens. We assessed the effects …
against PCSK9 is critical for selecting optimal dosing regimens. We assessed the effects …