User profiles for Pete Vogel
Peter VogelComparative Pathology Core Laboratory, St Jude Children's Research Hospital Verified email at stjude.org Cited by 28028 |
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over the
resting state. Although a role for the metabolic switch to glycolysis has been suggested to …
resting state. Although a role for the metabolic switch to glycolysis has been suggested to …
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer.
Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a …
Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a …
[HTML][HTML] TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
…, EP Williams, D Yang, E Fitzpatrick, P Vogel… - Nature …, 2021 - nature.com
The innate immune response is critical for recognizing and controlling infections through the
release of cytokines and chemokines. However, severe pathology during some infections, …
release of cytokines and chemokines. However, severe pathology during some infections, …
Acoustic control by wave field synthesis
AJ Berkhout, D de Vries, P Vogel - … Journal of the Acoustical Society of …, 1993 - pubs.aip.org
The acoustics in auditoria are determined by the properties of both the direct sound and the
later arriving reflections. If electroacoustic means are used to repair disturbing deficiencies in …
later arriving reflections. If electroacoustic means are used to repair disturbing deficiencies in …
[PDF][PDF] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
lung damage associated with patient mortality. While multiple inflammatory cytokines are …
[PDF][PDF] The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
Decreased expression of the Nlrp3 protein is associated with susceptibility to Crohn's disease.
However, the role of Nlrp3 in colitis has not been characterized. Nlrp3 interacts with the …
However, the role of Nlrp3 in colitis has not been characterized. Nlrp3 interacts with the …
mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental
inputs, including immune signals and metabolic cues, to direct T-cell fate decisions 1 . The …
inputs, including immune signals and metabolic cues, to direct T-cell fate decisions 1 . The …
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract
5-Hydroxytryptamine (serotonin) (5-HT) is a neurotransmitter with both central and peripheral
functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal (GI) …
functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal (GI) …
Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Regulatory T cells (T reg cells) have a crucial role in the immune system by preventing
autoimmunity, limiting immunopathology, and maintaining immune homeostasis 1 . However, …
autoimmunity, limiting immunopathology, and maintaining immune homeostasis 1 . However, …
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
The interferon (IFN)–inducible protein Z-DNA binding protein 1 [ZBP1; also known as DNA-dependent
activator of IFN regulatory factors (DAI) and DLM-1] was identified as a double-…
activator of IFN regulatory factors (DAI) and DLM-1] was identified as a double-…