Total synthesis of bryostatin 2
DA Evans, PH Carter, EM Carreira… - Journal of the …, 1999 - ACS Publications
The total synthesis of the marine macrolide bryostatin 2 is described. The synthesis plan
relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present …
relies on aldol and directed reduction steps in order to construct the anti-1,3-diol array present …
Highly selective inhibition of tyrosine kinase 2 (TYK2) for the treatment of autoimmune diseases: discovery of the allosteric inhibitor BMS-986165
…, WJ Pitts, L Lombardo, PH Carter… - Journal of Medicinal …, 2019 - ACS Publications
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating
autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally …
autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally …
Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α
PH Carter, PA Scherle… - Proceedings of the …, 2001 - National Acad Sciences
The binding of tumor necrosis factor alpha (TNF-α) to the type-1 TNF receptor (TNFRc1)
plays an important role in inflammation. Despite the clinical success of biologics (antibodies, …
plays an important role in inflammation. Despite the clinical success of biologics (antibodies, …
… -Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8 …
…, L Salter-Cid, JC Barrish, PH Carter… - Journal of medicinal …, 2016 - ACS Publications
Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec family
of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well …
of kinases. BTK plays an essential role in B cell receptor (BCR)-mediated signaling as well …
Discovery of branebrutinib (BMS-986195): a strategy for identifying a highly potent and selective covalent inhibitor providing rapid in vivo inactivation of Bruton's …
…, A Mathur, L Salter-Cid, JE Macor, PH Carter… - 2019 - ACS Publications
Bruton’s tyrosine kinase (BTK), a non-receptor tyrosine kinase, is a member of the Tec family
of kinases and is essential for B cell receptor (BCR) mediated signaling. BTK also plays a …
of kinases and is essential for B cell receptor (BCR) mediated signaling. BTK also plays a …
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity
…, A Fraley, RM Borzilleri, PH Carter… - Journal of Medicinal …, 2015 - ACS Publications
Affinity selection screening of macrocycle libraries derived from DNA-programmed
chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic …
chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic …
The roles of parathyroid hormone and calcitonin in bone remodeling: prospects for novel therapeutics
PH Carter, E Schipani - Endocrine, Metabolic & Immune …, 2006 - ingentaconnect.com
Inappropriate regulation of the bone resorption and bone formation processes that occur as
a normal part of bone remodeling can lead to net bone loss, as found in osteoporosis. …
a normal part of bone remodeling can lead to net bone loss, as found in osteoporosis. …
Asymmetric synthesis of bryostatin 2
DA Evans, PH Carter, EM Carreira… - Angewandte Chemie …, 1998 - Wiley Online Library
The potent bryostatin antitumor agents are currently in phase II clinical trials for the treatment
of a variety of forms of cancer. Aldol reactions and directed reductions are among the …
of a variety of forms of cancer. Aldol reactions and directed reductions are among the …
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine …
…, JR Burke, L Lombardo, PH Carter… - Journal of Medicinal …, 2019 - ACS Publications
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important
role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and …
role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and …
Discovery of BMS-986202: a clinical Tyk2 inhibitor that binds to Tyk2 JH2
…, LJ Lombardo, JE Macor, PH Carter… - Journal of Medicinal …, 2020 - ACS Publications
A search for structurally diversified Tyk2 JH2 ligands from 6 (BMS-986165), a pyridazine
carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development …
carboxamide-derived Tyk2 JH2 ligand as a clinical Tyk2 inhibitor currently in late development …